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citations
Cited by 9 publications
(9 citation statements)
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References 8 publications
(9 reference statements)
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“…The transcription factor nuclear factor erythroid 2-related factor (Nrf2) is known for its involvement in the regulation of AKR1B10 in addition to its role in the adoptive response to oxidative stress and damage [ 25 , 52 ], which is considered as one leading theory of aging [ 53 ]. Oxidative stress refers to the accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in cells, exceeding the cellular antioxidant capacity, and therefore, damaging cellular DNA, lipids, and proteins [ 54 , 55 ].…”
Section: Discussionmentioning
confidence: 99%
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“…The transcription factor nuclear factor erythroid 2-related factor (Nrf2) is known for its involvement in the regulation of AKR1B10 in addition to its role in the adoptive response to oxidative stress and damage [ 25 , 52 ], which is considered as one leading theory of aging [ 53 ]. Oxidative stress refers to the accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in cells, exceeding the cellular antioxidant capacity, and therefore, damaging cellular DNA, lipids, and proteins [ 54 , 55 ].…”
Section: Discussionmentioning
confidence: 99%
“…Oxidative stress refers to the accumulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in cells, exceeding the cellular antioxidant capacity, and therefore, damaging cellular DNA, lipids, and proteins [ 54 , 55 ]. Levels of accumulation increase with age, leading to a significant decline in cellular functions and repairing systems (including DNA repairing system) [ 53 ]. In general, hepatic cells have a high antioxidant ability when compared to other types of human cells; however, due to the functions of hepatic cells, accumulation of oxidative damage is quite easy to happen [ 56 ].…”
Section: Discussionmentioning
confidence: 99%
“…Its dysregulation is associated with the development of various cancers. The function of AKR1B10 in the development of inflammatory and infectious diseases is unknown ( 4 , 9 , 14 , 15 ).…”
Section: Discussionmentioning
confidence: 99%
“…AKR1B10 interferes with cell survival by modulating lipid synthesis, mitochondrial function, and oxidative status, implying that it is an important protein in cell survival mechanisms ( 3 ). In the intestine, AKR1B10 is expressed specifically by the epithelial cells and is secreted into the lumen ( 4 ). It is also commonly expressed in the adrenal gland and might have a significant function in liver carcinogenesis.…”
Section: Introductionmentioning
confidence: 99%
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