Akinetic Mutism With an Epidermoid Cyst of the 3rd Ventricle

Cairns, Hugh; Oldfield, R. C.; Pennybacker, Joe; Whitteridge, D.

doi:10.1093/brain/64.4.273

Cited by 315 publications

(94 citation statements)

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“…[13][14][15] The notion of apathy as a clinical syndrome was built from original case reports and lesional studies describing patients with fairly well preserved cognition who showed a striking absence of observable spontaneous active behaviours, but who were still capable of reacting and behaving almost normally in response to external stimulation. 16,17 Many descriptive epithets have been ascribed to this unique combination of an absence of self-initiated goal-directed actions-giving the patient the aspect of indiff erence, fl attening of aff ect, or emptiness of mind-and diminished responsiveness to stimuli. The diff erent terms used to describe the features of apathy can be regarded as describing a continuum of severity of reduced motivated behaviours, up to the most severe forms of akinetic mutism, abulia, athymhormia, or autoactivation defi cits.…”

Section: Conceptual Issuesmentioning

confidence: 99%

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Pagonabarraga

Kulisevsky

Strafella

et al. 2015

The Lancet Neurology

422

394

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Normal maintenance of human motivation depends on the integrity of subcortical structures that link the prefrontal cortex with the limbic system. Structural and functional disruption of diff erent networks within these circuits alters the maintenance of spontaneous mental activity and the capacity of aff ected individuals to associate emotions with complex stimuli. The clinical manifestations of these changes include a continuum of abnormalities in goal-oriented behaviours known as apathy. Apathy is highly prevalent in Parkinson's disease (and across many neurodegenerative disorders) and can severely aff ect the quality of life of both patients and caregivers. Diff erentiation of apathy from depression, and discrimination of its cognitive, emotional, and auto-activation components could guide an individualised approach to the treatment of symptoms. The opportunity to manipulate dopaminergic treatment in Parkinson's disease allows researchers to study a continuous range of motivational states, from apathy to impulse control disorders. Parkinson's disease can thus be viewed as a model that provides insight into the neural substrates of apathy.

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Section: Conceptual Issuesmentioning

confidence: 99%

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Pagonabarraga

Kulisevsky

Strafella

et al. 2015

The Lancet Neurology

422

394

View full text Add to dashboard Cite

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“…It is informative that a severe loss of both endogeneously and externally guided action can be encountered in another neurological condition, akinetic mutism (Cairns et al, 1941;Devinsky et al, 1995;Rietveld, 2008b). These patients neither speak nor act; they lack initiative.…”

Section: Utilization Behaviormentioning

confidence: 99%

Context-Switching and Responsiveness to Real Relevance

Rietveld¹

2012

Heidegger and Cognitive Science

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“…2) The causative damage may be maximal in regions adjacent to the third ventricle. 5) This region contains monoaminergic projection fibers from the brain stem. 21,23) Akinetic mutism does not result from simple elevation of intracranial pressure, 5) which is consistent with clinical observations of patients with pseudotumor cerebri, who can experience pronounced elevation of intracranial pressure without becoming mute.…”

Section: Discussionmentioning

confidence: 99%

Akinetic Mutism Responsive to Bromocriptine Following Subdural Hematoma Evacuation in a Patient With Hydrocephalus -Case Report-

Kim

Rhee

Lee

et al. 2007

Neurol. Med. Chir.(Tokyo)

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An 11-year-old girl with obstructive hydrocephalus developed akinetic mutism after treatment for hydrocephalus due to aqueductal stenosis by ventriculoperitoneal (VP) shunting. Bilateral chronic subdural hematomas developed about 2 months after insertion of the VP shunt and were evacuated. Postoperatively, the patient developed akinetic mutism, but her condition improved after administration of bromocriptine. Absence of abnormalities on dopamine transporter single photon emission computed tomography, lack of clinical response to levodopa treatment, and normal homovanillic acid concentration in the cerebrospinal fluid all indicated normal dopamine production. Pressure on the periventricular monoamine projections in the thalamus and hypothalamus without major dopamine deprivation in the striatum may have been the most important factors in the development of akinetic mutism in this patient.

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Akinetic Mutism With an Epidermoid Cyst of the 3rd Ventricle

Cited by 315 publications

References 0 publications

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment

Context-Switching and Responsiveness to Real Relevance

Akinetic Mutism Responsive to Bromocriptine Following Subdural Hematoma Evacuation in a Patient With Hydrocephalus -Case Report-

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