Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: Involvement of MAPK signal pathway

Yu, Xiao; Wang, Linna; Ma, Lin; You, Ran; Cui, Ran; Ji, De; Wu, Yue; Zhang, Chunfeng; Yang, Zhonglin; Ji, Hui

doi:10.1016/j.pbb.2012.02.014

Cited by 36 publications

(28 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…significantly improved the learning and memory abilities impaired by nucleus basalis magnocellularis (NBM) injury, protected neurons and markedly improved the activities of cholinergic enzyme, as reported in the literature (Yu et al, 2012b). These findings suggested that ASD might be a potential agent for the treatment of AD.…”

Section: Discussionsupporting

confidence: 75%

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

Akebia Saponin D (ASD) or asperosaponin VI is the most abundant constituent of the rhizome of Dipsacus asper, which has been used for the treatment of lower back pain, traumatic hematoma and bone fractures. In recent years, it was reported that ASD was a potential treatment strategy for Alzheimer's disease (AD). However, the low bioavailability of ASD limited its clinical utility. Microcrystalline preparation is one of the effective methods to improve drug absorption. The drugs prepared by different methods can present different solid forms (polymorphs), and different polymorphs have significantly different bioavailabilities. The objective of this study was to prepare ASD polymorphs using the different preparation processes and to evaluate their physicochemical properties and oral absorption. ASD-2 obtained by the antisolvent process was simpler and had higher recovery (78.5%) than that of ASD-1 by a two-step macroporous resin column separation (56.5%). The ASD polymorphs were characterized using differential scanning calorimetry (DSC), thermogravimetry analysis (TGA), powder X-ray diffraction (PXRD) and scanning electron microscopy (SEM). The results revealed that ASD-2 existed in microcrystalline form, while ASD-1 was amorphous. Furthermore, the equilibrium solubility, dissolution in aqueous solution and pharmacokinetic parameters of the samples were determined. ASD-2 showed lower aqueous solubility than that of ASD-1 (p < 0.01). In addition, ASD-2 showed lower dissolution with only 65% of the drug released while ASD-1 had a higher dissolution with 99% of drug released at the end of the 180 min testing period. Although ASD-1 significantly increased solubility and dissolution, the AUC 0-20h of ASD-2 was 4.3 times that of the amorphous ASD-1 in vivo. Data suggest that the microcrystalline preparation of ASD-2 is not only reasonable in economy and suitable for large-scale preparation, but also a promising method to enhance bioavailability of ASD.

show abstract

Section: Discussionsupporting

confidence: 75%

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Akebia saponin D could significantly improve the learning and memory abilities impaired by nucleus basalis magnocellularis injury, protect neurons and markedly increase ACh level and ChAT activity, and obviously decrease AChE activity (Yu et al , ).…”

Section: Saponins As Potential Therapeutic Agents In Neurodegenerativmentioning

confidence: 99%

“…It activated ERK 1/2 and PI3-kinase/Akt via TrkA, which is responsible for the induction of the neuritic process (Hur et al, 2009). Akebia saponin D might have an anti-apoptosis effect, which probably is attributed to the regulation of MAPK involved in signaling pathway (Yu et al, 2012).…”

Section: Relevant Signaling Pathwaysmentioning

confidence: 99%

Neuroprotection by Saponins

Sun

Lin

et al. 2014

Phytother. Res.

View full text Add to dashboard Cite

Saponins, an important group of bioactive plant natural products, are glycosides of triterpenoid or steroidal aglycones. Their diverse biological activities are ascribed to their different structures. Saponins have long been recognized as key ingredients in traditional Chinese medicine. Accumulated evidence suggests that saponins have significant neuroprotective effects on attenuation of central nervous system disorders, such as stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, our understanding of the mechanisms underlying the observed effects remains incomplete. Based on recently reported data from basic and clinical studies, this review highlights the proposed mechanisms of their neuroprotective function including antioxidant, modulation of neurotransmitters, anti-apoptosis, anti-inflammation, attenuating Ca(2+) influx, modulating neurotrophic factors, inhibiting tau phosphorylation, and regeneration of neural networks.

show abstract

“…The roots of DAW have been used for hundreds of years as an anti-osteoporosis, tonic, and antiaging agent in China for the therapy of low back pain, traumatic hematoma, threaten abortion, and bone fractures (7). As a typical compound of DAW, the protective effect of Akebia saponin D (ASD) (Fig.…”

Section: Introductionmentioning

confidence: 99%

“…As a typical compound of DAW, the protective effect of Akebia saponin D (ASD) (Fig. 1) has been described in some disease models such as cancer (8), Alzheimer's disease (7,9), cardiovascular disease (2,10,11), and bone fractures (12,13). Our previous studies have shown that ASD has a hepatoprotective effect in a mouse model (14).…”

Section: Introductionmentioning

confidence: 99%

Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction

Gong

Wang

2014

J Pharmacol Sci

View full text Add to dashboard Cite

Abstract. Akebia saponin D (ASD) is a typical bioactive triterpenoid saponin obtained from the rhizome of Dipsacus asper Wall. Previous studies have found that ASD has a hepatoprotective effect in a mouse model. The purpose of this paper was to explore the molecular mechanism of the hepatoprotective effects of ASD on BRL cells and isolated rat liver mitochondria. We investigated the effects of ASD on rotenone-induced toxicity in BRL cells. The results showed that ASD inhibited the accumulation of reactive oxidant species, ATP deficiency, and mitochondrial membrane potential dissipation; ameliorates mitochondrial respiratory dysfunction, and improved the activity of complex I in a concentration-dependent manner, indicating that ASD likely improved mitochondrial function. ASD suppressed rotenone-induced BRL cell apoptosis and increased Bcl-2/Bax ratio. These results suggest that ASD may exert hepatoprotective effects against rotenone-induced toxicity through mitochondria. This study supports our previous research that ASD possesses hepatoprotective activity in vivo and it is worthy of further study.

show abstract

Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: Involvement of MAPK signal pathway

Cited by 36 publications

References 42 publications

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

Microcrystalline Preparation of Akebia Saponin D for its Bioavailability Enhancement in Rats

Neuroprotection by Saponins

Protective Effects of Akebia Saponin D Against Rotenone-Induced Hepatic Mitochondria Dysfunction

Contact Info

Product

Resources

About