Airway remodeling contributes to the progressive loss of lung function in asthma: An overview

Pascual, Rodolfo M.; Peters, Stephen P.

doi:10.1016/j.jaci.2005.07.011

Cited by 309 publications

(256 citation statements)

References 88 publications

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“…In humans with asthma, increased airway smooth muscle mass also is seen. 18,19 Glucocorticoids and b 2 agonists can attenuate the proliferative response of airway smooth muscle. Use of glucocorticoids arrests cell cycle progression but results in an increase in airway smooth muscle cell size.…”

Section: Discussionmentioning

confidence: 99%

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Lung Function and Airway Cytologic Profiles in Horses with Recurrent Airway Obstruction Maintained in Low‐Dust Environments

Miskovic

Couëtil

Thompson

2007

Veterinary Internal Medicne

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Background: The effects of long-term environmental management on airway obstruction and inflammation in horses with recurrent airway obstruction (RAO) are unknown.Hypothesis: Horses with RAO maintained in low-dust environments have persistent airway obstruction and neutrophilic inflammation.Animals: Study horses were treated for RAO and then maintained in low-dust environments with no medical management. Horses were classified into 3 groups by years after diagnosis: 1 year (time 1, n 5 9), 2-3 years (time 2, n 5 7), and 5-6 years (time 3, n 5 8). The comparison groups were age-matched healthy horses.Methods: In this cross-sectional study, a clinical examination was performed, and the clinical score was calculated. Standard lung function, forced expiratory maneuvers, and the cytology of bronchoalveolar lavage fluid (BALF) were evaluated.Results: The clinical scores of the RAO horses were higher than those of the non-RAO horses at time 2 (P 5 .018). Standard lung function data were not different between the groups at any time point. The forced expiratory flow between 75-95% of exhaled vital capacity was lower in RAO horses than in non-RAO horses at all time points (P , .02), indicating persistent peripheral airway obstruction. Cytologic evaluation of BALF revealed no difference in total nucleated cell numbers or differential cell counts between RAO and non-RAO horses at any time point.Conclusions and Clinical Importance: The peripheral airway obstruction detected in horses with RAO maintained in lowdust environments likely is due to irreversible airway remodeling but is not associated with cytologic evidence of airway inflammation.

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Section: Discussionmentioning

confidence: 99%

“…18 b 2 agonists decrease airway smooth muscle DNA synthesis and smooth muscle cell numbers. 18,19 Prolonged treatment with glucocorticoids and b 2 agonists in combination may decrease the extent of airway smooth muscle remodeling.…”

Section: Discussionmentioning

confidence: 99%

Lung Function and Airway Cytologic Profiles in Horses with Recurrent Airway Obstruction Maintained in Low‐Dust Environments

Miskovic

Couëtil

Thompson

2007

Veterinary Internal Medicne

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“…Asthma is associated with airway inflammation. During the course of the disease, an airway remodeling usually develops that includes epithelial damage, smooth muscle and mucus gland hyperplasia, bronchial hyper-responsiveness, angiogenesis, collagen deposition and airway wall fibrosis [21]. Mediators released by epithelial cells and invading leukocytes such as cytokines (TNF-α, IL-1β), growth factors (TGF-β, GM-CSF, EGF) and endothelins (ET-1) are largely involved in the inflammation process and airways remodeling [22,23] by strongly regulating the gene expression pattern and the activation state of many different target cells.…”

Section: A C C E P T E D Article In Pressmentioning

confidence: 99%

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Garbacki¹,

Valentin²,

Piette³

et al. 2009

Pulmonary Pharmacology & Therapeutics

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“…Airway remodeling, defined as cellular and molecular architecture changes that manifest as structural alterations in the airway wall, may be a major contributor to lung function decline in asthma (6). AHR is governed by the contraction of ASM, the key regulator of bronchomotor tone, and is defined as exaggerated narrowing of the airway to stimuli (7,8).…”

mentioning

confidence: 99%

Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?

Ojiaku

Yoo

Panettieri

2017

Am J Respir Cell Mol Biol

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The pathogenesis of asthma includes a complex interplay among airway inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that airway structural cells, including bronchial smooth muscle cells, myofibroblasts, fibroblasts, and epithelial cells, mediate all three aspects of asthma pathogenesis. Although studies show a connection between airway remodeling and changes in bronchomotor tone, the relationship between the two remains unclear. Transforming growth factor b1 (TGF-b1), a growth factor elevated in the airway of patients with asthma, plays a role in airway remodeling and in the shortening of various airway structural cells. However, the role of TGF-b1 in mediating airway hyperresponsiveness remains unclear. In this review, we summarize the literature addressing the role of TGF-b1 in airway remodeling and shortening. Through our review, we aim to further elucidate the role of TGF-b1 in asthma pathogenesis and the link between airway remodeling and airway hyperresponsiveness in asthma and to define TGF-b1 as a potential therapeutic target for reducing asthma morbidity and mortality.

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Airway remodeling contributes to the progressive loss of lung function in asthma: An overview

Cited by 309 publications

References 88 publications

Lung Function and Airway Cytologic Profiles in Horses with Recurrent Airway Obstruction Maintained in Low‐Dust Environments

Lung Function and Airway Cytologic Profiles in Horses with Recurrent Airway Obstruction Maintained in Low‐Dust Environments

Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?

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