Airway Microstructure in Idiopathic Pulmonary Fibrosis: Assessment at Hyperpolarized ³He Diffusion-weighted MRI

Abstract

This is a repository copy of Airway microstructure in idiopathic pulmonary fibrosis: assessment at hyperpolarized 3He diffusion-weighted MRI.

Airspace Dimension Assessment (AiDA) by inhaled nanoparticles: benchmarking with hyperpolarised 129Xe diffusion-weighted lung MRI

“…Previous studies have shown that 3 He and 129 Xe ADC is highly repeatable in COPD patients with a coefficient of variation of 2.98% and 2.77% respectively, over 5 visits 32 . Similarly it has been showed that 3 He Lm D in patients with idiopathic pulmonary fibrosis is highly repeatable with a 0.6% difference between same-day visits 20 .…”

“…These in vivo distal airspace measurements from hyperpolarised gas DW-MRI have shown good agreement with direct morphometric measurements in validation studies with lung specimens 8,10,11 . Numerous studies have used hyperpolarised gas DW-MRI to elucidate changes in distal airspaces related to smoking [12][13][14] , ageing 15 , lung inflation 16 , and diseases such as COPD 17,18 , asthma 19 , and idiopathic pulmonary fibrosis (IPF) 20 . However, due to the high cost and complex infrastructure required for hyperpolarised gas MRI, the technique is not typically employed in standard pulmonary function testing or screening for pulmonary disease.…”

ERS International Congress, Madrid, 2019: highlights from the Clinical Techniques, Imaging and Endoscopy Assembly

“…More specifically, previous studies have shown that hyperpolarised gas diffusion-weighted (DW) MRI provides a noninvasive, quantitative assessment of microstructural acinar changes in the lung [ 38 ]. However, the utility of 129-xenon diffusion imaging has not been studied previously in ILDs; it was evaluated in a prospective, multicentre trial for the first time and presented at the congress.…”

Detection of Longitudinal Microstructural Changes in Idiopathic Pulmonary Fibrosis with Hyperpolarized 3He Diffusion-weighted MRI

“…Chan et al (7) found that 3 He DW MRI depicted changes in IPF over time. In particular, global mean diffusion length increased at 12 months in the base and periphery of the lungs, whereas pulmonary function tests did not demonstrate any significant change.…”

“…In conclusion, hyperpolarized gas MRI has proven to be to be a useful research tool that provides unique functional and structural information about the lungs and new insights into a variety of lung diseases. The study by Chan et al (7) demonstrates that 3 He DW MRI can provide global and regional assessment of the extent and severity of disease in patients with IPF, and excellent longitudinal assessment. 3 He DW MRI has the potential to become a sensitive outcome measure to depict, or even help predict, response to therapy sensitively and noninvasively.…”