Airway Epithelium in Atopic and Nonatopic Asthma: Similarities and Differences

Pillai, Prathap; Corrigan, Chris J.; Ying, Sun

doi:10.5402/2011/195846

Cited by 22 publications

(21 citation statements)

References 44 publications

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“…[ 27 28 ] We and others have previously reported that the expression of some CXC and CC cheomokines and their receptors are elevated in airways of asthma in a limited numbers of subjects. [ 10 29 30 31 ] Thus, in the present study, we also analyzed a number of CXC and CC motif chemokines in the BALF of asthmatics and controls. Our data showed that the median concentrations of CXCL10 (IP-10), CCL11 (eotaxin), CCL17 (TARC), and CCL4 (MIP-1) were significantly elevated in the BALF of asthmatics compared with controls, with increases accompanying disease severity.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics

Yang

et al. 2017

Chinese Medical Journal

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Background:Increased proinflammatory cytokines and chemokines might contribute to infiltration of inflammatory cells and remodeling in airways of asthma. Although these molecules may be associated with asthma, there is lack of systemic evidence showing which and how important these events are in the disease. We aimed to analyze the concentrations of these molecules in the airways and relationships with disease severity and with airway infiltration of inflammatory cells in a large cohort of asthmatics (n = 70, including 37 mild and 33 moderate/severe asthmatics) compared with controls (n = 30).Methods:Meso scale discovery system and commercial ELISA kits were used to measure the concentrations of proinflammatory cytokines interleukin (IL)-1β; tumor necrosis factor-alpha (TNF-α); IL-6; and IL-17 and CC and CXC chemokines CCL2, CCL4, CCL11, CCL13, CCL17, CCL22, and CCL26 and CXCL8, CXCL9, CXCL10, and CXCL11 in bronchoalveolar lavage fluid of asthmatics and controls.Results:The concentrations of IL-1, TNF-α, IL-6, CXCL8 and CXCL10, and CCL4, CCL11, CCL17, and CCL22 were significantly elevated in asthmatics compared with controls (P < 0.05). The concentrations of TNF-α and CXCL8, but not others, were negatively correlated with severity of disease (lung function forced expiratory volume in 1 s) (TNF-α vs. total: r = −0.359, P = 0.002 vs. moderate/severe: r = −0.541, P = 0.001; CXCL8 vs. total: r = −0.327, P = 0.006 vs. moderate/severe: r = −0.625, P = 0.0001, respectively). In addition, concentrations of these two molecules were also correlated with the absolute numbers of infiltrating eosinophils and neutrophils in asthmatic airways.Conclusions:Increased concentrations of TNF-α and CXCL8 are associated with pathogenesis of asthma. Targeting these molecules might provide an alternative therapeutic for this disease.

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Section: Discussionmentioning

confidence: 99%

Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics

Yang

et al. 2017

Chinese Medical Journal

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“…There is ongoing debate as to whether atopic asthma and non-atopic asthma are two immunopathologically distinct entities or if both are driven by similar mechanisms [37]. There is evidence supporting the concept that IgE-mediated mechanisms play a major role in asthma pathogenesis.…”

Section: Fibrinolysismentioning

confidence: 99%

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Bazan-Socha

Mastalerz

Cybulska

et al. 2016

Clin Experimental Allergy

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“…For example, in cases of allergic asthma, environmental control is performed differently, and patients can benefit from anti-IgE and immunotherapy [21,22]. …”

Section: Introductionmentioning

confidence: 99%

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

Takejima

Agondi²,

Rodrigues³

et al. 2017

Int Arch Allergy Immunol

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Background: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. Methods: A total of 109 patients with asthma were prospectively followed during 2 years. They were divided into 2 groups, i.e., allergic and nonallergic asthma, according to their clinical history and skin prick test and serum-specific immunoglobulin E (IgE) results. The control group comprised 297 deceased donors of solid organs. Patients' features and HLA class I and II genotypes were assessed and compared. Results: This study showed different features between asthma phenotypes. Nonallergic patients were older at the onset of asthma symptoms and had a higher rate of intolerance to nonsteroidal anti-inflammatory drugs. Allergic patients had higher total serum IgE levels, reported atopic dermatitis and rhinoconjunctivitis more frequently, and, unexpectedly, had a greater disease severity. New associations between the HLA genotypes and allergic and nonallergic asthma were identified. The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype. The presence of the haplotype HLA-DPA1*03 DQA*05 was associated with allergic asthma, and the presence of HLA-DPA1*03 and the absence of HLA-DQA*05 with nonallergic asthma. Conclusions: Allergic and nonallergic asthma have distinct phenotypic and genotypic features. New associations between asthma phenotypes and HLA class I and II were identified.

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Airway Epithelium in Atopic and Nonatopic Asthma: Similarities and Differences

Cited by 22 publications

References 44 publications

Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics

Characteristics of Proinflammatory Cytokines and Chemokines in Airways of Asthmatics

Asthma is associated with enhanced thrombin formation and impaired fibrinolysis

Allergic and Nonallergic Asthma Have Distinct Phenotypic and Genotypic Features

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