Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice

Eckrich, Jonas; Frenis, Katie; Blanco, Giovanny Rodriguez; Ruan, Yue; Jiang, Subao; Jiménez, María Teresa Bayo; Kuntic, Marin; Oelze, Matthias; Hahad, Omar; Li, Huige; Gericke, Adrian; Steven, Sebastian; Strieth, Sebastian; Kriegsheim, Alex von; Münzel, Thomas; Ernst, Benjamin Philipp; Daiber, Andreas

doi:10.1016/j.redox.2021.102063

Cited by 24 publications

(38 citation statements)

References 70 publications

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“…Furthermore, considering the stability of the albumin nanocarriers, evaluation of specific effects of encapsulation might also be influenced by the limited observation period when using the dorsal skinfold chamber model. Additionally, the observational quality can be improved by intravascular application of fluorophores allowing a more precise evaluation of the vascular network [23,48,49,55]. Therefore, further experiments evaluating the influence of surface modification with albumin nanocarriers on biological effects are urgently needed and longer observation periods should be considered to determine the specific effect of encapsulation especially when high molar substances are encapsulated.…”

Section: Discussionmentioning

confidence: 99%

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Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

et al. 2021

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Background: Porous polyethylene (PPE) implants are used for the reconstruction of tissue defects but have a risk of rejection in case of insufficient ingrowth into the host tissue. Various growth factors can promote implant ingrowth, yet a long-term gradient is a prerequisite for the mediation of these effects. As modification of the implant surface with nanocarriers may facilitate a long-term gradient by sustained factor release, implants modified with crosslinked albumin nanocarriers were evaluated in vivo. Methods: Nanocarriers from murine serum albumin (MSA) were prepared by an inverse miniemulsion technique encapsulating either a low- or high-molar mass fluorescent cargo. PPE implants were subsequently coated with these nanocarriers. In control cohorts, the implant was coated with the homologue non-encapsulated cargo substance by dip coating. Implants were consequently analyzed in vivo using repetitive fluorescence microscopy utilizing the dorsal skinfold chamber in mice for ten days post implantation. Results: Implant-modification with MSA nanocarriers significantly prolonged the presence of the encapsulated small molecules while macromolecules were detectable during the investigated timeframe regardless of the form of application. Conclusions: Surface modification of PPE implants with MSA nanocarriers results in the alternation of release kinetics especially when small molecular substances are used and therefore allows a prolonged factor release for the promotion of implant integration.

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Section: Discussionmentioning

confidence: 99%

“…For the PPE implantation, male C57BL/6J mice (Janvier, Le Genest-Saint-Isle, France), aged > 6 weeks (>25 g body weight) were used as experimental animals. Chamber preparation was performed as recently described by our working group [48,49]. After chamber preparation, in order to avoid injuries inflicted by other mice, animals were isolated.…”

Section: Animalsmentioning

confidence: 99%

Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

et al. 2021

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“…For the specific research performed by our working group [11] , male C57BL/6j or gp91phox −/y mice, aged > 8 weeks (>25 g body weight) are used as an experimental model, however, for other mouse strains, including immune deficient mice, chamber preparation and intravital analysis has also been described with some modifications [12] , [13] , [14] , [15] , [16] . All animal experiments were approved by the Landesuntersuchungsamt Koblenz, Germany (23 177-07/G 18-1-084 and addenda).…”

Section: Dorsal Skinfold Chamber Preparationmentioning

confidence: 99%

“…1 Surgical anatomy and technical equipment of the dorsal skinfold chamber in mice. Reused from [11] with permission. …”

Section: Dorsal Skinfold Chamber Preparationmentioning

confidence: 99%

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In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in mice

Eckrich¹,

Ruan

Jiang

et al. 2021

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This article contains supporting information on data collection for the research article entitled “Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice” by Eckrich et al. We found that noise-induced stress triggered microvascular dysfunction via involvement of innate immune-derived reactive oxygen species. In this article, we present the instrumentation of mice with dorsal skinfold chambers for in vivo microscopic imaging of blood flow, interaction of leukocytes with the vascular wall (also by fluorescent labelling of blood cells) and vessel diameter. In addition, we explain the preparation of cerebral arterioles for measurement of vascular reactivity in vitro . visualization of noise-dependent effects in dorsal skinfold chamber. in vivo microscopy of noise-dependent activation of white blood cells. analysis of noise-dependent microvascular dysfunction in dorsal skinfold chamber and cannulated cerebral arterioles.

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Road traffic noise exposure and its impact on health: evidence from animal and human studies—chronic stress, inflammation, and oxidative stress as key components of the complex downstream pathway underlying noise-induced non-auditory health effects

Arregi,

Vegas,

Lertxundi

et al. 2024

Environ Sci Pollut Res

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In heavily urbanized world saturated with environmental pollutants, road traffic noise stands out as a significant factor contributing to widespread public health issues. It contributes in the development of a diverse range of non-communicable diseases, such as cardiovascular diseases, metabolic dysregulation, cognitive impairment, and neurodegenerative disorders. Although the exact mechanisms behind these non-auditory health effects remain unclear, the noise reaction model centres on the stress response to noise. When exposed to noise, the body activates the hypothalamic–pituitary–adrenal axis and the sympathetic nervous system, leading to the secretion of stress hormones like catecholamines and cortisol. Prolonged exposure to noise-induced stress results in chronic inflammation and oxidative stress. This review underscores the role of inflammation and oxidative stress in the progression of noise-induced vascular dysfunction, disruption of the circadian rhythm, accelerated aging, neuroinflammation, and changes in microbiome. Additionally, our focus is on understanding the interconnected nature of these health outcomes: These interconnected factors create a cascade effect, contributing to the accumulation of multiple risk factors that ultimately lead to severe adverse health effects.

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Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice

Cited by 24 publications

References 70 publications

Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

Surface Modification of Porous Polyethylene Implants with an Albumin-Based Nanocarrier-Release System

In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in mice

Road traffic noise exposure and its impact on health: evidence from animal and human studies—chronic stress, inflammation, and oxidative stress as key components of the complex downstream pathway underlying noise-induced non-auditory health effects

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