Air pollution and children's respiratory symptoms in six cities of Northern China

Pan, Guowei; Zhang, Shujuan; Feng, Ying; Takahashi, Ken; Kagawa, Jun; Yu, Lei; Wang, Ping; Liu, Meijuan; Qi-nan, Liu; Hou, Shuwen; Bai-ling, Pan; Li, Jianping

doi:10.1016/j.rmed.2010.07.018

Cited by 71 publications

(53 citation statements)

References 28 publications

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“…Environmental factors, such as air pollution, may be responsible. High levels of outdoor air pollution are positively associated with persistent cough in China [31,32].…”

Section: Discussionmentioning

confidence: 99%

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

et al. 2014

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Reports from individual centres suggest a preponderance of females with chronic cough. Females also have heightened cough reflex sensitivity. Here we have reviewed the age and sex of unselected referrals to 11 cough clinics. To investigate the cause of any observed sex dimorphism, functional magnetic resonance imaging of putative cough centres was analysed in normal volunteers.The demographic profile of consecutive patients presenting with chronic cough was evaluated. Cough challenge with capsaicin was undertaken in normal volunteers to construct a concentration-response curve. Subsequent functional magnetic resonance imaging during repeated inhalation of sub-tussive concentrations of capsaicin observed areas of activation within the brain and differences in the sexes identified.Of the 10 032 patients presenting with chronic cough, two-thirds (6591) were female (mean age 55 years). The patient profile was largely uniform across centres. The most common age for presentation was 60-69 years. The maximum tolerable dose of inhaled capsaicin was lower in females; however, a significantly greater activation of the somatosensory cortex was observed.Patients presenting with chronic cough from diverse racial and geographic backgrounds have a strikingly homogeneous demographic profile, suggesting a distinct clinical entity. The preponderance of females may be explained by sex-related differences in the central processing of cough sensation. @ERSpublications Chronic cough in specialist clinics have homogenous demographic profiles, suggesting single clinical entity

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“…Environmental factors, such as air pollution, may be responsible. High levels of outdoor air pollution are positively associated with persistent cough in China [31,32].…”

Section: Discussionmentioning

confidence: 99%

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

et al. 2014

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“…In the study by Dong et al (2011), the associations were reduced from an OR of 1.19 (95% CI: 1.06-1.34) per 10 μg/m 3 in males and an OR of 1.14 (95% CI: 0.99-1.30) in females to an OR of 0.97 for both sexes in a five-pollutant model. In Pan et al (2010), the effect estimates for current asthma associated with NO 2 were strongly reduced and lost statistical significance in a three-pollutant model with total suspended particulates and SO 2 (total suspended particulates and NO 2 were correlated with r = 0.6). Sahsuvaroglu et al (2009) investigated asthma prevalence in schoolchildren in Hamilton, Canada.…”

Section: Long Term Effects On Asthmamentioning

confidence: 92%

“…There are also a range of cross-sectional studies that investigated within-community exposure contrasts, more representative of traffic pollution, which have not been reviewed here, but include many positive associations with NO 2 , some of which are statistically significant. Three of the recent area studies on asthma prevalence included multipollutant models (Dong et al, 2011;Pan et al, 2010;Sahsuvaroglu et al, 2009). In the study by Dong et al (2011), the associations were reduced from an OR of 1.19 (95% CI: 1.06-1.34) per 10 μg/m 3 in males and an OR of 1.14 (95% CI: 0.99-1.30) in females to an OR of 0.97 for both sexes in a five-pollutant model.…”

Section: Long Term Effects On Asthmamentioning

confidence: 99%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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“…Surrounded by mountains, the climate of LanzhouXigu is characterized by very stable atmospheric stratification with strong atmospheric inversion extending to the afternoon which hinders the diffuse out of air pollutants. Heavy PAHs emissions have been occurring in Xigu (Zhang et al 2000;Pan et al 2010;Gao et al 2007;Tao et al 2012). It has been reported that cancer-standardized rate of local population in Xigu was the highest (192.84/10) in Lanzhou (Zhang et al 2011).…”

Section: Targeted Populationmentioning

confidence: 99%

Cancer risk of petrochemical workers exposed to airborne PAHs in industrial Lanzhou City, China

Wang

Zhao

Liu

et al. 2015

Environ Sci Pollut Res

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This paper reports the connections between red blood cells abnormality risk of petrochemical workers and their exposure to airborne polycyclic aromatic hydrocarbons (PAHs). Urinary 1-hydroxypyrene (1-OHP), as the biomarker of PAHs exposure, was adopted to assess the exposure risk of the petrochemical workers to PAHs in Xigu, the west suburb of Lanzhou where petrochemical industries are located. Fifty-three workers, sub-grouped to 36 petrochemical workers and 17 office workers, participated in this investigation. Logistic regression model and spearman correlation analysis were performed to estimate the associations between PAHs exposure levels and red blood cells abnormality risk of petrochemical workers. Strong associations between some red cell indices (MCH, MCHC, RDW) and 1-OHP concentration were found. Results also show that the red blood cells abnormality risk increased with increasing PAHs exposure level. Compared with office workers, risk level of red blood cells abnormality in petrochemical workers was higher by 41.7 % (OR, 1.417; 95 % CI: 0.368-5.456) than that in office workers. This result was verified by the tissue-to-human blood partition coefficient for pyrene and 1-OHP. The quantitative assessments of the potential health risk through inhalation exposure to PAHs were conducted using the Incremental Lifetime Cancer Risk (ILCR) model. It was found the ILCR from inhalation exposure to PAHs for the petrochemical workers ranged from 10(-5) to 10(-4) with 95 % probability, indicating that petrochemical plant workers were under a high potential cancer risk level.

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Air pollution and children's respiratory symptoms in six cities of Northern China

Abstract: The high levels of outdoor air pollution in north China are positively associated with children's respiratory symptoms, the associations with TSP appear to be stronger than SO(2) and NO(2).

Cited by 71 publications

References 28 publications

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

A worldwide survey of chronic cough: a manifestation of enhanced somatosensory response

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Cancer risk of petrochemical workers exposed to airborne PAHs in industrial Lanzhou City, China

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