AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

Rotondi, Sandra; Oliva, Maria Antonietta; Esposito, Vincenzo; Ventura, Laura; Giangaspero, Felice; Alesse, Edoardo; Jaffrain-Réa, Marie-Lise

doi:10.1530/endoabs.35.p835

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“…Rotondi et al . [ 11 ] suggested that the gonadotroph phenotype was strongly associated with AIP expression in NFPAs. The AIP level is higher in GnPA than that in ncPA, and both AIP and cyclinD1 levels are high in most NFPAs.…”

Section: Introductionmentioning

confidence: 99%

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Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas

Qiao

Wang

et al. 2016

Balkan Journal of Medical Genetics

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Microarray data of non-functioning pituitary adenomas (NFPAs) were analyzed to disclose novel genes and pathways involved in NFPA tumorigenesis. Raw microarray data were downloaded from Gene Expression Omnibus. Data pre-treatment and differential analysis were conducted using packages in R. Functional and pathway enrichment analyses were performed using package GOs-tats. A protein-protein interaction (PPI) network was constructed using server STRING and Cytoscape. Known genes involved in pituitary adenomas (PAs), were obtained from the Comparative Toxicogenomics Database. A total of 604 differentially expressed genes (DEGs) were identifed between NFPAs and controls, including 177 up- and 427 down-regulated genes. Jak-STAT and p53 signaling pathways were significantly enriched by DEGs. The PPI network of DEGs was constructed, containing 99 up- and 288 down-regulated known disease genes (e.g. EGFR and ESR1) as well as 16 up- and 17 down-regulated potential novel NFPAs-related genes (e.g. COL4A5, LHX3, MSN, and GHSR). Genes like COL4A5, LHX3, MSN, and GHSR and pathways such as p53 signaling and Jak-STAT signaling, might participate in NFPA development. Although further validations are required, these findings might provide guidance for future basic and therapy researches.

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Section: Introductionmentioning

confidence: 99%

“…The AIP level correlates with follicle-stimulating hormone β (FSHβ) and cyclinD1 levels in GnPA. However, AIP is not involved in the aggressiveness of NFPAs [ 11 ]. Recently, CCNB1 was found to mediate the proliferation-inhibiting role of miR-410, a small non-coding RNA, in GnPA [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas

Qiao

Wang

et al. 2016

Balkan Journal of Medical Genetics

View full text Add to dashboard Cite

show abstract

AIP expression in non-functioning pituitary adenomas is strongly associated with the gonadotroph phenotype but not with tumour aggressiveness

Cited by 1 publication

References 0 publications

Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas

Microarray technology reveals potentially novel genes and pathways involved in non-functioning pituitary adenomas

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