Biochemical Pharmacology volume 77, issue 4, P498-507 2009 DOI: 10.1016/j.bcp.2008.09.025 View full text
Lijoy K. Mathew, Michel T. Simonich, Robert L. Tanguay

Abstract: AbstractThe origins of molecular toxicology can be traced to understanding the interactions between halogenated aromatic hydrocarbons and the aryl hydrocarbon receptor (AHR). The physiological consequences of activation of the aryl hydrocarbon receptor are diverse, and we are just beginning to understand the importance of the AHR signal transduction pathway in homeostasis and disease. The many downstream targets that mediate these biological responses remain undefined. Studies have exploited the power of the …

expand abstract