Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

0
3
0

Year Published

2018
2018
2020
2020

Publication Types

Select...
3

Relationship

0
3

Authors

Journals

citations
Cited by 5 publications
(3 citation statements)
references
References 8 publications
(6 reference statements)
0
3
0
Order By: Relevance
“…This low intensity and chronic inflammatory microenvironment promoted tumorigenesis and progression. In elderly patients, proliferation and activity of CD4+ and CD8+ T cells and B cells decreased, while those of immunosuppressive cells increased (53), which formed an immunosuppressive microenvironment that facilitated tumor progression (16). However, few prospective clinical trials have focused on the elderly, and limited studies have demonstrated that older patients benefit from chemotherapy as well as targeted therapies but exhibit more severe cardiotoxicity and bone marrow disorders (54).…”
Section: Discussionmentioning
confidence: 99%
“…This low intensity and chronic inflammatory microenvironment promoted tumorigenesis and progression. In elderly patients, proliferation and activity of CD4+ and CD8+ T cells and B cells decreased, while those of immunosuppressive cells increased (53), which formed an immunosuppressive microenvironment that facilitated tumor progression (16). However, few prospective clinical trials have focused on the elderly, and limited studies have demonstrated that older patients benefit from chemotherapy as well as targeted therapies but exhibit more severe cardiotoxicity and bone marrow disorders (54).…”
Section: Discussionmentioning
confidence: 99%
“…Metabolic fitness declines upon aging. Mitochondrial functions decrease due to accumulating mitochondrial DNA mutations, decreasing further the ability of TILs to compete for glucose in the tumor microenvironment 178. Oxidative stress also leads to mitochondrial fragmentation and aging 179.…”
Section: Mitochondria Related Gene Alterations Oxidation Mechanismsmentioning
confidence: 99%
“…Although PD-1 blockade immunotherapy has vastly changed the landscape of treatment of some cancers (melanoma, lung cancer), many cancer patients still do not favorably respond to immunotherapy (19,20). The lack of response is attributed to an overall exhaustion of T cells caused by mitochondrial dysfunction and decreased energy metabolism.…”
Section: Role Of Ros In Cancer Biology and Immunotherapymentioning
confidence: 99%