volume 27, issue 4, P753-765 2011
DOI: 10.3233/jad-2011-110686
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Maitrayee Sinha, Prajna Behera, Pritha Bhowmick, Kalpita Banerjee, Sumitran Basu, Sasanka Chakrabarti

Abstract: The entangled relationship of brain aging, mitochondrial dysfunction, and amyloid-β peptide (Aβ₄₂) toxicity occupies the center stage in the pathogenesis of Alzheimer's disease (AD). The present study examines some of the toxic effects of Aβ₄₂ on brain mitochondria and provides evidence that aged brain mitochondria are significantly more vulnerable to Aβ₄₂ toxicity. In particular, the study has shown that the aggregated, but not the monomeric, form of Aβ₄₂ in varying concentrations (10-40 μM) during in vitro i…

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