2022
DOI: 10.3390/ijms232113085
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Abstract: The proportion of elderly people in the world population is constantly increasing. With age, the risk of numerous chronic diseases and their complications also rises. Research on the subject of cellular senescence date back to the middle of the last century, and today we know that senescent cells have different morphology, metabolism, phenotypes and many other characteristics. Their main feature is the development of senescence-associated secretory phenotype (SASP), whose pro-inflammatory components affect tis… Show more

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Cited by 15 publications
(3 citation statements)
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“…87 Compared to that of the young, liver volume in elderly adults is reduced by 20-40%, hepatocytes are more susceptible to stress, and the risk of chronic liver disease is greater. 88 With increasing age, the physiological structure of the kidney also changes with the number of functional glomeruli decreasing, leading to the decline of renal function. 89 Once an elderly person develops chronic kidney disease, the probability of acute kidney injury increases.…”
Section: Basic Physiology Of the Elderlymentioning
confidence: 99%
“…87 Compared to that of the young, liver volume in elderly adults is reduced by 20-40%, hepatocytes are more susceptible to stress, and the risk of chronic liver disease is greater. 88 With increasing age, the physiological structure of the kidney also changes with the number of functional glomeruli decreasing, leading to the decline of renal function. 89 Once an elderly person develops chronic kidney disease, the probability of acute kidney injury increases.…”
Section: Basic Physiology Of the Elderlymentioning
confidence: 99%
“…The process of aging is associated with gradual deterioration of hepatic function and structure accompanied by various changes in liver cells such as sinusoidal endothelial cells 4 . More seriously, aging can also increase mortality risk from various liver diseases as an adverse prognostic factor 5 . To date, although a few studies 6 8 including a small number of subjects have used ultrasound to measure portal blood flow and shed light on the effect of the age on the hemodynamic circumstances in the PV, the hemodynamic characteristics of the PV including the volume and velocity of the blood flow through the PV with age remain poorly understood.…”
Section: Introductionmentioning
confidence: 99%
“…As a result, nuclear DNA damage caused by mitochondrial malfunction results in cell necrosis. With age, liver cells change under the in uence of various stressors and the risk of developing liver diseases [14]. It has been shown that aging aggravates APAP-induced acute liver injury and in ammation [15].…”
Section: Introductionmentioning
confidence: 99%