2016
DOI: 10.18632/aging.100894
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Abstract: Aging is a major risk factor for several conditions including neurodegenerative, cardiovascular diseases and cancer. Functional impairments in cellular pathways controlling genomic stability, and immune control have been identified. Biomarker of immune senescence is needed to improve vaccine response and to develop therapy to improve immune control. To identify phenotypic signature of circulating immune cells with aging, we enrolled 1068 Chinese healthy volunteers ranging from 18 to 80 years old. The decreased… Show more

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Cited by 98 publications
(87 citation statements)
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References 37 publications
(39 reference statements)
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“…Hence, we cannot exclude effects of immunosenescence within the comparisons of the study group and HC. However, the biggest changes in relative and absolute lymphocyte subsets occur during infancy, adolescence and in elderly patients >70 years ( 24 , 54 ). As the oldest COVID-19 patient in our study was 71 years of age, effects of immunosenescence should not have critically altered the comparability.…”
Section: Discussionmentioning
confidence: 99%
“…Hence, we cannot exclude effects of immunosenescence within the comparisons of the study group and HC. However, the biggest changes in relative and absolute lymphocyte subsets occur during infancy, adolescence and in elderly patients >70 years ( 24 , 54 ). As the oldest COVID-19 patient in our study was 71 years of age, effects of immunosenescence should not have critically altered the comparability.…”
Section: Discussionmentioning
confidence: 99%
“…Older age is associated both with decreasing lymphocyte count, 31,35 which we found in this study, and with mortality. Although the reason for the age-associated decline in lymphocyte count is not known, possible explanations may include age-related thymic involution, which leads to a change in the composition of lymphocyte subsets with age, [36][37][38] and, as a consequence, a change in overall immune competence. 39,40 The higher mortality risk shown among those with lymphopenia who were younger than 70 years of age compared with those aged 70 years or older suggests that factors other than age might contribute to the high mortality risk, such as poor immune surveillance, iatrogenic causes (i.e., medications) and blood donations or transfusions.…”
Section: Discussionmentioning
confidence: 99%
“…A further analysis of lymphocytes from alveolar lavage fluid is needed. Third, the expression of some immunological markers, such as CD28 and CD45RO, is different in different age stages (23). Therefore, continuously monitoring host immunity in the same patients is needed.…”
Section: I N I C a L M E D I C I N Ementioning
confidence: 99%