volume 8, issue 5, P848-859 2016
DOI: 10.18632/aging.100894
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Ling Qin, Xie Jing, Zhifeng Qiu, Wei Cao, Yang Jiao, Jean-Pierre Routy, Taisheng Li

Abstract: Aging is a major risk factor for several conditions including neurodegenerative, cardiovascular diseases and cancer. Functional impairments in cellular pathways controlling genomic stability, and immune control have been identified. Biomarker of immune senescence is needed to improve vaccine response and to develop therapy to improve immune control. To identify phenotypic signature of circulating immune cells with aging, we enrolled 1068 Chinese healthy volunteers ranging from 18 to 80 years old. The decreased…

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