2020
DOI: 10.1101/2020.06.26.170043
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Abstract: The aging process is characterized by an accumulation of cellular damage, including alterations to the epigenome. While it is clear that DNA methylation patterns change with age, the mechanisms behind these epigenomic alterations - and their functional consequences - have remained unclear. One of the primary roles of DNA methylation in mammalian genomes is in the repression of retrotransposons. Many of these repetitive elements contain regulatory sequences, and loss of repression can lead to aberrant t… Show more

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Cited by 1 publication
(3 citation statements)
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“…p < 0.005, adj. p < 0.1) and was highly enriched in DMRs that were hypomethylated in the older cells ( Figures S3Li-ii), supporting our earlier findings based on a more limited set of whole genome bisulfite sequencing (WGBS) data in LEPs [Senapati et al, 2020].…”
Section: These Molecular Changes Recapitulated Previous Phenotypic Obsupporting
confidence: 88%
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“…p < 0.005, adj. p < 0.1) and was highly enriched in DMRs that were hypomethylated in the older cells ( Figures S3Li-ii), supporting our earlier findings based on a more limited set of whole genome bisulfite sequencing (WGBS) data in LEPs [Senapati et al, 2020].…”
Section: These Molecular Changes Recapitulated Previous Phenotypic Obsupporting
confidence: 88%
“…Hypomethylation of this CpG island region in older LEPs was confirmed in our WGBS dataset [Senapati et al, 2020] (Figure S7Hi). This 5-CpG DMR was located in the first intron ( Figure S7Hi), a region that has been shown to have inverse correlation between intron methylation and gene expression [Anastasiadi et al, 2018].…”
Section: Dnam Changessupporting
confidence: 60%
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