2016
DOI: 10.18632/aging.101082
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Abstract: Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old mammary glands of different cohorts of C57BL6/J and BALB/c mice, and our findings revealed that old mammary glands were characterized by increased basal cell pool comprised of mostly CD49fhi cells,… Show more

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Cited by 11 publications
(24 citation statements)
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References 67 publications
(86 reference statements)
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“…Future studies may focus on the inflammatory cytokines and immune cell types enriched in aged mammary glands as detected herein to further delineate their exact contribution to tumor formation and progression. Of note, basal-like luminal cells have been reported in aged mice with mammary hyperplasia and in older women ( Dong et al, 2016 ; Garbe et al, 2012 ; Pelissier Vatter et al, 2018 ), but are undetectable in our healthy aged mice, suggesting that these cells might represent a more-aberrant population that is usually absent in normal murine mammary glands.…”
Section: Discussionmentioning
confidence: 64%
See 1 more Smart Citation
“…Future studies may focus on the inflammatory cytokines and immune cell types enriched in aged mammary glands as detected herein to further delineate their exact contribution to tumor formation and progression. Of note, basal-like luminal cells have been reported in aged mice with mammary hyperplasia and in older women ( Dong et al, 2016 ; Garbe et al, 2012 ; Pelissier Vatter et al, 2018 ), but are undetectable in our healthy aged mice, suggesting that these cells might represent a more-aberrant population that is usually absent in normal murine mammary glands.…”
Section: Discussionmentioning
confidence: 64%
“…Although recent single-cell RNA sequencing (scRNA-seq) studies have characterized changes during embryonic development, puberty, and pregnancy ( Bach et al, 2017 ; Giraddi et al, 2018 ; Pal et al, 2017 ; Wuidart et al, 2018 ), little is known about the alterations associated with aging, an important aspect of mammary development closely related to breast cancer ( Jenkins et al, 2014 ). Although mammography, histology, and molecular analyses have revealed prominent changes with age, including decreased mammographic density, altered epithelial proportions, and reduced connective tissue ( Azam et al, 2019 ; Dong et al, 2016 ; Garbe et al, 2012 ; Gertig et al, 1999 ; Hart et al, 1989 ; Hutson et al, 1985 ; McCormack et al, 2010 ; Pelissier Vatter et al, 2018 ; Pelissier et al, 2014 ), systematic single-cell transcriptome profiling can better capture age-associated effects at a higher resolution and on a larger scale. Moreover, given that increased age is strongly associated with breast cancer susceptibility in human and mouse models ( Jenkins et al, 2014 ; LaBarge et al, 2016 ; Raafat et al, 2012 ), a single-cell atlas for aged mammary glands could help fill the gaps in our knowledge of aging and cancer risk.…”
Section: Introductionmentioning
confidence: 99%
“…In the bone marrow, CD49a and CD49f have been reported to be discriminant for cells endowed with higher multipotency and stemness status [41]. However, it has been also shown that, in mammary stem cells, aging is associated with an increased expression of CD49f paralleled by a decline in function and increased transformation potential [42]. Regarding CD49a, it has been reported that selection using this integrin enhances the multipotentiality of mesenchymal stem cells [43].…”
Section: Discussionmentioning
confidence: 99%
“…As a case in point, Garbe et al have shown the accumulation of multipotent progenitors during the aging of human mammary epithelia (7). Similarly, Dong et al have recently shown an age-associated increase in MaSC frequency in mouse mammary glands (6). Both reports described a decline in the function and an increased transformation potential of MaSC with aging.…”
Section: Fig 11mentioning
confidence: 97%
“…The well-known one is the procarcinogenic aging process, during which there is an accumulation of senescent cells, known to have proinflammatory and -tumorigenic paracrine effects mediated through the secretion of various cytokines and growth factors (3)(4)(5). Indeed, several lines of evidence indicated the presence of age-dependent accumulation of multipotent progenitor cells with a decline in function and alteration in the luminal-to-basal cell ratio (6,7). Moreover, senescence promoted cellular reprogramming in vivo through the secretion of high levels of interleukin-6 (IL-6) (8,9).…”
mentioning
confidence: 99%