volume 10, issue 7, P1597-1608 2018
DOI: 10.18632/aging.101495
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Hao Gu, Dong Liu, Xi Zeng, Liu-Sheng Peng, Yue Yuan, Zhi-Fu Chen, Quan-Ming Zou, Yun Shi

Abstract: Pneumonia caused by Acinetobacter baumannii has become a serious threat to the elderly. However, there are no experimental studies on the relevance between aging and A. baumannii infections. Here, we established an aged pneumonia mouse model by non-invasive intratracheal inoculation with A. baumannii. Higher mortality was observed in aged mice along with increased bacterial burdens and more severe lung injury. Increased inflammatory cell infiltration and enhanced pro-inflammatory cytokines at 24 hours post inf…

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