2016
DOI: 10.18632/aging.101124 View full text |Buy / Rent full text
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Abstract: Clinical data identify age as a factor for severe liver fibrosis. We evaluate whether and how aging modulates the fibrotic response in a mouse model. Liver fibrosis was induced by CCl4 injections (thrice weekly for 2 weeks) in 7 weeks- and 15 months-old mice (young and old, respectively). Livers were analyzed for fibrosis, inflammation and remodeling 48 and 96 hours after the last injection. Old mice developed more severe fibrosis compared to young ones as evaluated by sirius red morphometry. Expression of pro… Show more

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“…These include increased inflammation and immune response-related proteins [23], and accumulation of extracellular matrix proteins [32]. Interestingly, we found a statistically significant overlap between proteins differentially abundant in NMR vs. GP, and proteins whose abundance is affected by NMR aging (99 proteins, p=2x10 -4 , Fisher's exact test, Figure 3C).…”
Section: Cross-species-and Aging-related Changes Correlatementioning
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rupbmjkragerfmgwileyiopcupepmcmbcthiemesagefrontiersapsiucrarxivemeralduhksmucshluniversity-of-gavle
“…These include increased inflammation and immune response-related proteins [23], and accumulation of extracellular matrix proteins [32]. Interestingly, we found a statistically significant overlap between proteins differentially abundant in NMR vs. GP, and proteins whose abundance is affected by NMR aging (99 proteins, p=2x10 -4 , Fisher's exact test, Figure 3C).…”
Section: Cross-species-and Aging-related Changes Correlatementioning
“…We focused on a subset of tissues (i.e. heart, liver, cerebellum, olfactory bulb) that are known to display age-related functional decline (Enwere et al 2004;Sussman and Anversa 2004;Zhang et al 2010;Shioi and Inuzuka 2012;Mobley et al 2014;Delire et al 2016), and that are clearly anatomically defined. We also derived primary cultures of neural stem and progenitor (NSCs) from these young, middle-aged, and old mice.…”
Section: A Genome-wide Epigenomic and Transcriptomic Landscape Of In mentioning
“…NSCs cultures derived from the Subventricular Zone (SVZ) because (i) these tissues and cells are known to display age-related functional decline(Enwere et al 2004;Sussman and Anversa 2004;Zhang et al 2010;Shioi and Inuzuka 2012;Mobley et al 2014;Delire et al 2016) and (ii) the tissues are all clearly defined anatomically, which guarantees reproducible isolation across animals of different ages and minimizes the risk that observed differences comes from dissection differences. For the heart, we dissected the ventricle tissue for chromatin and RNA extraction.…”
mentioning
“…Young animals have a different ECM composition, higher regenerative capacity, and higher collagen turnover rate compared to old animals. (53,54) To address this issue, future studies using aged mice for evaluation of the RGD inhibitors are warranted.…”
Section: Discussionmentioning