Aging changes of the testis in albino rat: light, electron microscopic, morphometric, immunohistochemical and biochemical study

The possible protective role of Coenzyme Q10 on the testis of rats treated with cisplatin

“…This toxicity was associated with extensive tubular atrophy induced by enormous construction of ROS performed by cisplatin administration (Azu et al, 2010). Indeed, we observed in the present study significant increases in collagen fibers deposition in the testes tissues from cisplatin treated rats when stained with Masson's trichrome as compared to control group, indicating to fibrosis to play critical role in testis dysfunction as reported previously (Hussein et al, 2020).…”

Role of soy isoflavone in preventing aging changes in rat testis: Biochemical and histological studies

“…In elderly adults, disruption of the Sertoli-to-Sertoli junction associated to abnormal spermatogenesis and weakening of immunological barrier provided by blood testis barrier ( Jiang et al, 2014 , Santiago et al, 2019 ). In concomitant with histopathological alterations observed in ( Hussein et al, 2020 ) research, in senile Brown Norway rats, regressed tubules with degraded germ cells and wide intercellular gaps were discovered ( LEVY et al, 1999 ). One interesting result noted in ( Hussein et al, 2020 ) study was elevated in Leydig cells number in interstitium around atrophic tubules.…”

“…In concomitant with histopathological alterations observed in ( Hussein et al, 2020 ) research, in senile Brown Norway rats, regressed tubules with degraded germ cells and wide intercellular gaps were discovered ( LEVY et al, 1999 ). One interesting result noted in ( Hussein et al, 2020 ) study was elevated in Leydig cells number in interstitium around atrophic tubules. Other investigators found elevated in Leydig cells number and size with aging ( Dakouane et al, 2005 , Xu et al, 2013 ).…”

“…As a result, ageing testes experience significant histological and morphological changes, resulting in decreased testicular function ( Matzkin et al, 2016 ). According to ( Hussein et al, 2020 ) the most essential markers for sustaining the cells' redox status are assessed NO, MDA, and GSH in testicular tissue. Senescence in reproductive cells causes the formation of oxygen free radicals in Leydig cells and sperm mitochondria, led to disruption of sperm telomere, Leydig cells steroidogenesis, and presence of mitochondrial DNA in both cells ( Desai et al, 2010 ).…”

“…Recent research has connected prolonged paternal age to congenital malformations such as Down syndrome, cancers such as leukemia, CNS neoplasms, and a variety of neuropsychiatric disorders in kids ( Gunes et al, 2016 ). Atrophic tubules were seen beside tubules with normal spermatogenesis in both humans and animals, indicating that aging-related atrophy begins in seminiferous tubules ( Hussein et al, 2020 ).…”