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Cited by 5 publications
(4 citation statements)
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References 7 publications
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“…Cellular senescence plays an important role in wound healing and cancer suppression, as well as contributing to age-related tissue dysfunction [ 25 , 26 ]. Senescent cells accumulate with age in most, if not all, vertebrate tissues, and are thought to promote many diseases of aging [ 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…Cellular senescence plays an important role in wound healing and cancer suppression, as well as contributing to age-related tissue dysfunction [ 25 , 26 ]. Senescent cells accumulate with age in most, if not all, vertebrate tissues, and are thought to promote many diseases of aging [ 27 ].…”
Section: Introductionmentioning
confidence: 99%
“…From 2010 to 2030, the aging of the US population will lead to a 67% increase in the incidence of cancer among Americans over 65 years of age (Smith et al 2009 ). With the accumulation of senescent cells, the expression of SASP will increase and promote an inflammatory state, enhancing the invasive capabilities and accelerating the progression of cancer (Faget et al 2019 ; Hartley et al 2017 ). NF-κB and p38MAPK signaling pathways play important roles in the release of SASPs, which promote epithelial-mesenchymal transition (EMT) in cancer cells (Coppé et al 2010 ).…”
Section: Age‐related Diseasesmentioning
confidence: 99%
“…It seems that aging, chronic degenerative diseases, and tumors affect the human body via different directions. Interestingly, aging and cancer also share similar expression characteristics, for example, the genomic stability during aging and cancer follows a similar pattern at the transcriptome level [5,6] and therapeutic interventions for one of these might allow dual benefits of anti-aging as well as cancer prevention. These strategies include, but are not limited to, caloric restriction [7], drug senolytics [8,9], and so on.…”
Section: Introductionmentioning
confidence: 99%