Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches

Kudryashova, Kseniya S.; Burka, Ksenia; Kulaga, Anton; Vorobyeva, Nataliya S.; Kennedy, Brian K.

doi:10.1002/pmic.201900408

Cited by 45 publications

(31 citation statements)

References 181 publications

(185 reference statements)

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“…Many studies have shown that age, gender, current health status, and mortality may aff ect telomere length that varies within the same group [9]. Telomere shortening is considered as an important biomarker (biological thermometer) [10]. Since it might be related to the replication problem phenomena, which says that DNA polymerases are not able to replicate in the linear chromosome that leads the telomeres to shorten after each cell division, consequently, this may be followed by cell death [11].…”

Section: Telomere Length Changes According To Age and Sexmentioning

confidence: 99%

Sex and Age Differences in Telomere Length and Susceptibility to COVID-19

Kamal¹,

Alamiry²,

Zaki³

2020

J Biomed Res Environ Sci

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Background: Telomeres are the ends of a chromosome and play a fundamental role as vanguards contra the chromosomal decay. Due to the inability of DNA polymerase to replicate chromosomal ends, a reduction in telomeres length happens after each cell division. The existence of shorter telomeres in older people is related to diminish immune functions. Viral infections able to stimulate remodeling of cells, stress responses, and telomere shortening. Moreover, telomere shortening can be caused by extrinsic environmental variables which induce oxidative stress under conditions of inflammation. Aim: To identify the correlation between telomere shortening and susceptibility to Novel Coronavirus Disease 2019 (COVID-19). In addition to clarifying changes in telomere length according to the viral infection, the effect of sex and age differences in telomere length in confirmed positive COVID-19 cases are also reviewed. Conclusion: There is a correlation between telomere length and COVID-19 infection with higher susceptibly of elderly patients and males due to shortening in their telomere length. Approximately 53% of (111,428) infected cases (≥ 50) years old are males, and 47% of (111,428) infected cases (≥ 50) years old are females.

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Section: Telomere Length Changes According To Age and Sexmentioning

confidence: 99%

Sex and Age Differences in Telomere Length and Susceptibility to COVID-19

Kamal¹,

Alamiry²,

Zaki³

2020

J Biomed Res Environ Sci

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“…We already know that the rate of aging is determined by our genomic constitution in combination with environmental factors, such as nutrition or physical activity, in addition to epigenetic patterns, which represent the interface between them (Adwan-Shekhidem and Atzmon 2018; Benayoun et al 2015). While our transcriptional, genetic and epigenetic landscapes are already useful to predict the expected lifespan and the rate of aging of an individual (Bell et al 2019;Kudryashova et al 2020), it is difficult to exert a direct influence on these. Thus, environmental factors (above all nutrition) are a primary target for people to combat aging.…”

Section: Introductionmentioning

confidence: 99%

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

et al. 2021

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Several biogerontology databases exist that focus on genetic or gene expression data linked to health as well as survival, subsequent to compound treatments or genetic manipulations in animal models. However, none of these has yet collected experimental results of compound-related health changes. Since quality of life is often regarded as more valuable than length of life, we aim to fill this gap with the “Healthy Worm Database” (http://healthy-worm-database.eu). Literature describing health-related compound studies in the aging model Caenorhabditis elegans was screened, and data for 440 compounds collected. The database considers 189 publications describing 89 different phenotypes measured in 2995 different conditions. Besides enabling a targeted search for promising compounds for further investigations, this database also offers insights into the research field of studies on healthy aging based on a frequently used model organism. Some weaknesses of C. elegans-based aging studies, like underrepresented phenotypes, especially concerning cognitive functions, as well as the convenience-based use of young worms as the starting point for compound treatment or phenotype measurement are discussed. In conclusion, the database provides an anchor for the search for compounds affecting health, with a link to public databases, and it further highlights some potential shortcomings in current aging research.

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“…For example, a recent study investigated the role of coiled-coil domain-containing protein 80 (CCDC80) gene in lipid metabolism by applying multi-omics integrative analysis and they found new roles of CCDC80 in fatty acid metabolism [157]. Moreover, multi-omics has been widely used for identifying molecular and non-molecular biomarkers [158,159]. Therefore, another benefit of large-scale multiomics is that it may predict lipid biomarkers, and it can be useful in precision medicine.…”

Section: Integration Of Multi-omicsmentioning

confidence: 99%

Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

Senevirathna

Asakawa

2021

Life

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Lipid synthesis pathways of toothed whales have evolved since their movement from the terrestrial to marine environment. The synthesis and function of these endogenous lipids and affecting factors are still little understood. In this review, we focused on different omics approaches and techniques to investigate lipid metabolism and radiation impacts on lipids in toothed whales. The selected literature was screened, and capacities, possibilities, and future approaches for identifying unusual lipid synthesis pathways by omics were evaluated. Omics approaches were categorized into the four major disciplines: lipidomics, transcriptomics, genomics, and proteomics. Genomics and transcriptomics can together identify genes related to unique lipid synthesis. As lipids interact with proteins in the animal body, lipidomics, and proteomics can correlate by creating lipid-binding proteome maps to elucidate metabolism pathways. In lipidomics studies, recent mass spectroscopic methods can address lipid profiles; however, the determination of structures of lipids are challenging. As an environmental stress, the acoustic radiation has a significant effect on the alteration of lipid profiles. Radiation studies in different omics approaches revealed the necessity of multi-omics applications. This review concluded that a combination of many of the omics areas may elucidate the metabolism of lipids and possible hazards on lipids in toothed whales by radiation.

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Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches

Cited by 45 publications

References 181 publications

Sex and Age Differences in Telomere Length and Susceptibility to COVID-19

Sex and Age Differences in Telomere Length and Susceptibility to COVID-19

Health and longevity studies in C. elegans: the “healthy worm database” reveals strengths, weaknesses and gaps of test compound-based studies

Multi-Omics Approaches and Radiation on Lipid Metabolism in Toothed Whales

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