2020
DOI: 10.1002/pmic.201900408
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Aging Biomarkers: From Functional Tests to Multi‐Omics Approaches

Abstract: Aging results in various deleterious changes in the human body that may lead to loss of function and the manifestation of chronic diseases. While diseases can generally be reliably diagnosed, the aging process itself requires more sophisticated approaches to evaluate its progression. Numerous attempts have been made to establish biomarkers to quantify human aging at the cellular, tissue, and organismal level. Here, an up‐to‐date overview of biomarkers related to human aging with an emphasis on biomarkers that … Show more

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Cited by 49 publications
(41 citation statements)
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References 181 publications
(185 reference statements)
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“…Another challenging topic discussed by Brian Kennedy, National University of Singapore, Singapore, related to the pros and cons of different ways of testing longevity interventions. Aging interventions would benefit most by applying prevention-based approaches and biomarker discovery [109]. Understanding how different physiological measures and aging clocks correspond to each other could allow targeted testing of different types of aging interventions, including the recently published life-extending molecule 2-oxoglutarate [110].…”
Section: Challenges In Aging: Science Society and Economymentioning
confidence: 99%
“…Another challenging topic discussed by Brian Kennedy, National University of Singapore, Singapore, related to the pros and cons of different ways of testing longevity interventions. Aging interventions would benefit most by applying prevention-based approaches and biomarker discovery [109]. Understanding how different physiological measures and aging clocks correspond to each other could allow targeted testing of different types of aging interventions, including the recently published life-extending molecule 2-oxoglutarate [110].…”
Section: Challenges In Aging: Science Society and Economymentioning
confidence: 99%
“…Many studies have shown that age, gender, current health status, and mortality may aff ect telomere length that varies within the same group [9]. Telomere shortening is considered as an important biomarker (biological thermometer) [10]. Since it might be related to the replication problem phenomena, which says that DNA polymerases are not able to replicate in the linear chromosome that leads the telomeres to shorten after each cell division, consequently, this may be followed by cell death [11].…”
Section: Telomere Length Changes According To Age and Sexmentioning
confidence: 99%
“…We already know that the rate of aging is determined by our genomic constitution in combination with environmental factors, such as nutrition or physical activity, in addition to epigenetic patterns, which represent the interface between them (Adwan-Shekhidem and Atzmon 2018; Benayoun et al 2015). While our transcriptional, genetic and epigenetic landscapes are already useful to predict the expected lifespan and the rate of aging of an individual (Bell et al 2019;Kudryashova et al 2020), it is difficult to exert a direct influence on these. Thus, environmental factors (above all nutrition) are a primary target for people to combat aging.…”
Section: Introductionmentioning
confidence: 99%