2017
DOI: 10.18632/aging.101232
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Abstract: Recent studies have discovered aging-associated changes of adult stem cells in various tissues and organs, which potentially contribute to the organismal aging. However, aging-associated changes of liver progenitor cells (LPCs) remain elusive. Employing young (2-month-old) and old (24-month-old) mice, we found diverse novel alterations in LPC activation during aging. LPCs in young mice could be activated and proliferate upon liver injury, whereas the counterparts in old mice failed to respond and proliferate, … Show more

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Cited by 23 publications
(18 citation statements)
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References 43 publications
(60 reference statements)
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“…Recently, Cheng et al [ 180 ] have demonstrated that oxidative stress inhibits liver progenitor cell (LPC) activation in aged mice during liver regeneration. In particular, they [ 180 ] have analyzed liver regeneration following choline devoid-ethionine supplemented (CDE) diet. This dietary regimen causes liver damage and expansion of LPCs, also known as ‘oval cells’ [ 181 ].…”
Section: Extra-cellular Factors Affecting Liver Regeneration In Aged mentioning
confidence: 99%
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“…Recently, Cheng et al [ 180 ] have demonstrated that oxidative stress inhibits liver progenitor cell (LPC) activation in aged mice during liver regeneration. In particular, they [ 180 ] have analyzed liver regeneration following choline devoid-ethionine supplemented (CDE) diet. This dietary regimen causes liver damage and expansion of LPCs, also known as ‘oval cells’ [ 181 ].…”
Section: Extra-cellular Factors Affecting Liver Regeneration In Aged mentioning
confidence: 99%
“…In the study of Cheng et al [ 180 ], it was shown that CDE administration induced LPC proliferation in young mice, but not in old animals. Loss of LPC proliferation was associated to the impairment of the regenerative response of aged livers.…”
Section: Extra-cellular Factors Affecting Liver Regeneration In Aged mentioning
confidence: 99%
See 1 more Smart Citation
“…Liver progenitor cells (LPCs) are quiescent cells that are activated during liver injury in order to regenerate the liver parenchyma. LPC functionality is negatively regulated by the aging process (74). LPCs in young mice could be activated and proliferate upon liver injury, whereas in old mice failed to respond and proliferate, leading to impaired liver regeneration.…”
Section: Liver Progenitor Cellsmentioning
confidence: 99%
“…This, in turn, enhances apoptosis, according to evidence from MMP-focused liver studies [ 85 , 86 ], by altering cell–matrix and cell–cell interactions, and by releasing apoptotic proteins. Additionally, a recent study by Cheng et al revealed that aging hepatic stellate cells activated neutrophils, which produced ROS that infiltrated into liver niches and caused maladaptive changes in liver progenitor cells in old mice, which might have led to stem cell senescence and apoptosis [ 87 ].…”
Section: Introductionmentioning
confidence: 99%