Aging and red blood cell membrane: a study of centenarians

Caprari, Patrizia; Scuteri, Angelo; Salvati, Anna Maria; Bauco, C.; Cantàfora, Alfredo; Masella, Roberta; Modesti, Daniela; Tarzia, Anna; Marigliano, Vincenzo

doi:10.1016/s0531-5565(98)00055-2

Cited by 61 publications

(31 citation statements)

References 31 publications

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“…Control values were obtained from a group of 10 children, age-matched with AEDS patients, and these were in agreement with data reported for normal subjects in the recent literature (37)(38)(39)(40). It is known that lipid composition of erythrocytes and lymphocytes in the elderly can vary (41) whereas it does not change consistently in young subjects (42).…”

Section: Resultssupporting

confidence: 86%

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Ferreri

Angelini

Chatgilialoglu

et al. 2005

Lipids

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The formation of trans FA residues in membrane phospholipids may be due to a free radical-catalyzed isomerization process occurring to the cis unsaturated FA moieties. Radical stress is well documented in inflammatory processes of atopic diseases, but no data are yet available about a possible association with trans FA detected in these patients. We investigated the presence of trans lipid isomers in the erythrocyte and T-lymphocyte membranes of 26 children affected by atopic eczema/dermatitis syndrome (AEDS). Trans lipid isomers were found in both cell membranes, up to a total content of 2.7 and 4.9% of the FA composition, respectively. By using the geometrical trans lipid library derived from in vitro models of thiyl radical-catalyzed isomerization, oleic and arachidonic acid isomers were detected. The statistical significance was evaluated by comparison with an age-matched control group. These results suggest the role of an endogenous free radical isomerization path occurring to membrane unsaturated lipids, complementary to the dietary contribution, which can be involved in the lipid impairment in AEDS. This study contributes to lipidomic research regarding the double bond structure and the influence of a geometrical change of membrane lipids in physiology and diseases.

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Section: Resultssupporting

confidence: 86%

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Ferreri

Angelini

Chatgilialoglu

et al. 2005

Lipids

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“…Erythrocyte fatty acid composition has been validated as a reliable biomarker of oxidative stress and consequently on the rate of aging and ultimately lifespan [4,5]. We have reported an association between a specific fatty acid profile of blood constituents and longevity [6].…”

Section: Introductionmentioning

confidence: 84%

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Genio¹

2015

J Diabetes Metab

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Background: Morbid obesity is a pathologic condition associated to an increased incidence of several chronic conditions associated to increased risk of mortality. Erythrocyte fatty acid composition has been candidate as a biomarker of oxidative stress and consequently on the rate of aging and ultimately lifespan. To our knowledge, no study has investigated the total spectrum of lipid composition of erythrocyte membranes from obese individuals. The aim of this study was to compare the fatty acid composition of erythrocyte membranes derived from morbidly obese patients with healthy matched controls and long-living descendants.Methods: Gas chromatography was employed to determine fatty acid percentage of erythrocyte membranes from investigated groups.Results: Erythrocyte membranes from obese subjects had significantly lower percentage of monounsaturated fatty acids (16.0 ± 0.8 vs. 23.0 ± 4.5, p<0.01) and total trans fatty acid (0.2 ± 0.1 vs. 1.3 ± 1.2, p<0.001) than controls. Obese fatty acid profiles showed increased percent of total polyunsaturated fatty acid (36.5 ± 1.4 vs. 27.3 ± 10.9, p<0.001), polyunsaturated fatty acid n-3 (5.2 ± 0.9 vs. 2.6 ± 1.8, p <0.001) and n-6 (31.3 ± 1.7 vs. 25.0 ± 10.1, p<0.001). Interestingly, when obese fatty acid profiles are compared with long-living descendants, the former show opposite trends in the percentages of the main saturated and unsaturated residues of membrane phospholipids compared with nonagenarian offspring. Conclusion:This study shows that the erythrocyte membranes fatty acid composition of obese subjects differs from general population in a way opposite to the long-living descendants. If confirmed by further investigations, the fatty acid equilibration may become an additional target in the multidisciplinary strategy aimed to treat the obesity epidemic.

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“…A reduced volume of intracellular compartments has been described with age in body composition studies [33]. Reduction of cell volume as a function of aging, due to change in the activity of ionic pumps or in the ability to adjust water uptake, has been described for other cell types such as blood red cells [34] and Leydig cells [35]. It is possible that reduction of water content in the zona might decrease its elasticity and impair the physiological hatching before implantation explaining a possible rationale for assisted hatching as suggested in more aged patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of oocyte morphometry parameters with woman’s age

Valeri

Pappalardo

Felici

et al. 2011

J Assist Reprod Genet

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Purpose Aim of this study was to evaluate morphometric parameters of metaphase II oocytes, including cytoplasm diameter (CD), zona pellucida thickness (ZPT) and width of the perivitelline space (PS), in relation with zona pellucida birefringence, spindle presence and age of the woman. Methods Oocytes were classified into groups according to zona birefringence (low or high zona birefringence, LZB and HZB, respectively) and presence or absence of a visible spindle (SP and aSP, respectively).Results HZB oocytes showed a thicker zona (17.7±0.3 μm) than LZB oocytes (16.7±0.3 μm, p<0.01). Moreover, PS was narrower in HZB and SP oocytes than in LZB (p< 0,001) and aSP (p<0,05) oocytes. Finally, we found that CD and ZPT linearly decrease with age of the woman (CD r= 0.028: p<0.01; ZPT r=0.050: p<0.0001). Conclusion Our results evidence an association in human oocytes between zona pellucida and spindle birefringence and defined morphometric parameters and a decrease of oocyte size and ZPT as a function of women's age.

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Aging and red blood cell membrane: a study of centenarians

Cited by 61 publications

References 31 publications

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Trans fatty acids and atopic eczema/dermatitis syndrome: The relationship with a free radical cis‐trans isomerization of membrane lipids

Morbid Obesity is Associated to Altered Fatty Acid Profile of Erythrocyte Membranes

Correlation of oocyte morphometry parameters with woman’s age

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