2018
DOI: 10.18632/aging.101612
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Abstract: Although there are numerous hypotheses explaining the nature of aging and associated processes, two concepts are dominant: (i) aging is a result of cell-autonomous processes, such as the accumulation of DNA mutations, aberrant methylations, protein defects, and shortening of telomeres, leading to either inhibition of cellular proliferation and death of non-dividing terminally differentiated cells or tumor development; (ii) aging is a result of a central program that is switched on at a specific stage of organi… Show more

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Cited by 10 publications
(5 citation statements)
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References 108 publications
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“…A miRNA interacts with its target genes to form a regulatory network, which acts in almost all life processes. It has been shown by many studies that miRNAs are a key group of important modulators in biological processes and play important roles in development [ 37 , 38 ], organogenesis [ 39 , 40 ], cell proliferation and differentiation [ 41 ], cell cycle regulation [ 41 , 42 ], cell apoptosis [ 43 , 44 , 45 ], aging [ 46 , 47 , 48 ], pathogenesis [ 49 , 50 ], cellular response to stresses [ 51 , 52 , 53 , 54 ], etc.…”
Section: Micrornasmentioning
confidence: 99%
“…A miRNA interacts with its target genes to form a regulatory network, which acts in almost all life processes. It has been shown by many studies that miRNAs are a key group of important modulators in biological processes and play important roles in development [ 37 , 38 ], organogenesis [ 39 , 40 ], cell proliferation and differentiation [ 41 ], cell cycle regulation [ 41 , 42 ], cell apoptosis [ 43 , 44 , 45 ], aging [ 46 , 47 , 48 ], pathogenesis [ 49 , 50 ], cellular response to stresses [ 51 , 52 , 53 , 54 ], etc.…”
Section: Micrornasmentioning
confidence: 99%
“…MicroRNAs (miRNAs) are small (about 22 nucleotides long), endogenous, non‐coding single‐stranded eukaryotic RNAs that can influence the expression of their target genes post‐transcriptionally [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Abnormal expression of miRNA‐145‐5p has a reported involvement in multiple cancers, including hepatocellular carcinoma, oesophageal carcinoma and lung cancer.…”
Section: Introductionmentioning
confidence: 99%
“…These morbidities drastically complicate a patient’s life and hasten mortality. It is worth noting that clinical manifestations of the abovementioned ARDs are preceded by long (10–20 years) asymptomatic periods of illness development [ 2 ]. If no changes are implemented, these trends will continue, and aging will become a significant social and economic burden [ 3 ].…”
Section: Introductionmentioning
confidence: 99%