Yang Li, Dan-yun Ruan, Chang-chang Jia, Jun Zheng, Guo-ying Wang, Hui Zhao, Qing Yang, Wei Liu, Shu-hong Yi, Hua Li, Gen-shu Wang, Yang Yang, Gui-hua Chen, Qi Zhang et al.
Abstract:Hepatic ischemia-reperfusion (I/R) injury fundamentally influences the performance of aged liver grafts. The significance of mitophagy in the age dependence of sensitivity to I/R injury remains poorly understood. Here, we show that aging aggravated hepatic I/R injury with decreased mitophagy in mice. The enhancement of mitophagy resulted in significant protection against hepatic I/R injury. Parkin, an E3 ubiquitin ligase, was found depleted by I/R in aged livers. In oxygen-glucose deprivation reperfusion (OGD-…
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