2012
DOI: 10.18632/aging.100501
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Abstract: Immunosenescence is a result of progressive decline in immune system function with advancing age. Epidermal Langerhans cells (LCs), belonging to the dendritic cell (DC) family, act as sentinels to play key roles in the skin immune responses. However, it has not been fully elucidated how aging affects development and function of LCs. Here, we systemically analyzed LC development and function during the aging process in C57BL/6J mice, and performed global microRNA (miRNA) gene expression profiles in aged and you… Show more

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Cited by 37 publications
(28 citation statements)
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References 58 publications
(78 reference statements)
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“…Xu, et al [92] report that Langerhans cells in the skin of aged mice display a unique microRNA (miRNA) pattern. MiRNAs are small, non-coding RNA molecules that are key regulators of gene expression by means of their capacity to limit translation of specific RNAs.…”
Section: Pulmonary Responsementioning
confidence: 99%
“…Xu, et al [92] report that Langerhans cells in the skin of aged mice display a unique microRNA (miRNA) pattern. MiRNAs are small, non-coding RNA molecules that are key regulators of gene expression by means of their capacity to limit translation of specific RNAs.…”
Section: Pulmonary Responsementioning
confidence: 99%
“…Then, cells were washed by phosphate buffered saline (PBS), and subsequently stained with anti-CD45.2 and MHC-II, the percentage of LCs that uptake antigen (CD45.2 + /MHC-II + /FITC + ) was determined by flow cytometry [74, 75]. …”
Section: Methodsmentioning
confidence: 99%
“…LCs are of special interest to us because the deletion of Dicer in DCs only affects the homeostasis and function of LCs, but not other types of DCs (Kuipers et al 2010;Xu et al 2012) giving a strong indication that miRNAs regulate LC development and function.…”
Section: Epidermal Langerhans Cells (Lcs) Are Langerin ?mentioning
confidence: 99%