Aggressive B-Cell Lymphomas

Yang, Wei; Listinsky, Catherine M.

doi:10.1007/0-387-32025-3_12

Cited by 4 publications

(5 citation statements)

References 19 publications

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“…Aquaporins are impermeable to protons and other inorganic and organic cations, with the possible exception of AQP1, although this is controversial [529]. One or more members of this family of proteins have been found to be expressed in almost all tissues of the body [reviewed in Yang (2017) [1184]]. AQPs are involved in numerous processes that include systemic water homeostasis, adipocyte metabolism, brain oedema, cell migration and fluid secretion by epithelia.…”

Section: Aquaporinsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

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The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15539. Ion channels are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.

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Section: Aquaporinsmentioning

confidence: 99%

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander

Mathie

Peters

et al. 2021

British J Pharmacology

203

167

View full text Add to dashboard Cite

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“…In stomatal guard cells, these pathways promote closure of the stomatal pore to resist water loss in ABA (water-stress hormone) or in drought stress (Xue et al, 2018) and to promote stomatal defence against bacterial pathogens (Baena et al, 2022). Aquaporins impact disease and pathogen immunity in both animals (Yang, 2017) and plants (Zhang et al, 2019;Zhang, Shi, et al, 2022) and are deemed critical for stomata-pathogen interactions, a pattern conserved across plant species (Rodrigues et al, 2017;Zhang et al, 2019). Our analysis shows that SYP132 regulation of PIP2;1 has coordinate and opposing effects on AHA1 binding with the SNARE (Figures 1 and 2).…”

Section: Pip2;1 and Aha1 In Environmental Responsementioning

confidence: 99%

“…Four PIP isoforms (PIP2;1, PIP2;2, PIP2;6 and PIP2;7) account for much of the hydraulic conductivity in the Arabidopsis rosette and three (PIP2;1, PIP2;2 and PIP2;4) affect guard cell water flux (Blatt et al, 2014;Ding & Chaumont, 2020;Grondin et al, 2015) and water permeation under abiotic stress (Grondin et al, 2015). Additionally, aquaporins are implicated in disease and pathogen immunity in both animals (Yang, 2017) and plants (Zhang et al, 2019). A stringent control of both PIP density and conductance regulates water transport across the plasma membrane in plant cells (Alexandersson et al, 2005;Chaumont & Tyerman, 2014;Hachez et al, 2013Hachez et al, , 2014Luu & Maurel, 2013).…”

Section: Introductionmentioning

confidence: 99%

Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress

Baena,

Xia,

Waghmare

et al. 2024

The Plant Journal

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SUMMARYIn plants so‐called plasma membrane intrinsic proteins (PIPs) are major water channels governing plant water status. Membrane trafficking contributes to functional regulation of major PIPs and is crucial for abiotic stress resilience. Arabidopsis PIP2;1 is rapidly internalised from the plasma membrane in response to high salinity to regulate osmotic water transport, but knowledge of the underlying mechanisms is fragmentary. Here we show that PIP2;1 occurs in complex with SYNTAXIN OF PLANTS 132 (SYP132) together with the plasma membrane H+‐ATPase AHA1 as evidenced through in vivo and in vitro analysis. SYP132 is a multifaceted vesicle trafficking protein, known to interact with AHA1 and promote endocytosis to impact growth and pathogen defence. Tracking native proteins in immunoblot analysis, we found that salinity stress enhances SYP132 interactions with PIP2;1 and PIP2;2 isoforms to promote redistribution of the water channels away from the plasma membrane. Concurrently, AHA1 binding within the SYP132‐complex was significantly reduced under salinity stress and increased the density of AHA1 proteins at the plasma membrane in leaf tissue. Manipulating SYP132 function in Arabidopsis thaliana enhanced resilience to salinity stress and analysis in heterologous systems suggested that the SNARE influences PIP2;1 osmotic water permeability. We propose therefore that SYP132 coordinates AHA1 and PIP2;1 abundance at the plasma membrane and influences leaf hydraulics to regulate plant responses to abiotic stress signals.

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“…[70] Curcumin also down-regulates transcription factor protein-1 (AP1) and nuclear factor kB (NFkB) which are pro inflammatory gene products; at the same time it also decreases the expression of inflammatory cytokines such as interleukin (IL)-8, IL-6, IL-1, TNF α thus, acting on the inflammatory, proliferative and maturation phases of wound healing. [71,72,70]…”

Section: Biocompatibilitymentioning

confidence: 99%

Synthesis and Characterization of Bacterial Cellulose‐Curcumin‐Ag‐Se Nanocomposites having Antioxidant and Antibacterial properties for Skin Healing Applications

Dias,

Nagar,

Bhende

et al. 2024

ChemistrySelect

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Bacterial Cellulose is a polymer synthesised by some strains of bacteria thus perceived as environmentally friendly. Bacterial Cellulose (BC) was subjected to three different drying procedures; Freeze Drying, Blot drying and Oven drying. Studies on its water holding capacity, thermogravimetric analysis and mechanical strength revealed that Freeze drying was the best method for retaining its pore size and water holding capacity. Silver selenium nanoparticles complexed with Curcumin (Cur‐AgSeNPs) were loaded on BC and characterised by FESEM, EDX, FTIR and XRD. The ultrastructure of the BC nanocomposite revealed a three‐dimensional network of interwoven cellulose microfibrils with the nanoparticle complex adsorbed onto the surface as well as embedded within the porous structure of the membrane. Antimicrobial analysis of the BCnanocomposite showed bactericidal activity against P. aeruginosa (MTCC 741), E. coli (MTCC 2574) and S. aureus (MTCC 737) cultures. 0.5 mM Cur‐AgSeNPs loaded BC film showed a Radical Scavenging Activity of 63.92±0.76 % by ABTS assay and a cell viability of 75 % after 4 days for L929 fibroblast cells. Haemocompatibility test of the films showed <10 % haemolysis of RBCs indicating their haemocompatible nature. These results suggest that the BCnanocomposite film would open up the possibility for use as an ideal skin healing material.

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Aggressive B-Cell Lymphomas

Cited by 4 publications

References 19 publications

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress

Synthesis and Characterization of Bacterial Cellulose‐Curcumin‐Ag‐Se Nanocomposites having Antioxidant and Antibacterial properties for Skin Healing Applications

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