Aggregation of meso-tetrakis(4-N-methyl-pyridiniumyl) porphyrin in its free base, Fe(III) and Mn(III) forms due to the interaction with DNA in aqueous solutions: Optical absorption, fluorescence and light scattering studies

Gandini, Shirley C.M.; Borissevitch, Iouri; Perussi, Janice Rodrigues; Imasato, Hidetake; Tabak, Marcel

doi:10.1016/s0022-2313(97)00278-0

Cited by 55 publications

(32 citation statements)

References 30 publications

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“…These metalloporphyrins usually exist as monomers in acidic solution and form the l-oxo-dimers upon alkalinization. Interaction of water-soluble Fe(III)-porphyrins with DNA [19], albumin [20] and micelles [21] has been investigated. It has been suggested that a metalloporphyrin having superoxide dismutase (SOD) activity is a new class of anticancer agents [22].…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide transfer from the NO-donor S-nitroso-N-acetylpenicillamine to monomers and dimers of water-soluble iron-porphyrins

Vilhena

Louro

2004

Journal of Inorganic Biochemistry

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Section: Introductionmentioning

confidence: 99%

Nitric oxide transfer from the NO-donor S-nitroso-N-acetylpenicillamine to monomers and dimers of water-soluble iron-porphyrins

Vilhena

Louro

2004

Journal of Inorganic Biochemistry

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“…Fluorescence spectroscopy is an important method for studying the interaction of small molecules and DNA [29,30]. Fluorescence emission spectra of the two porphyrins were recorded in the presence and absence of CT DNA.…”

Section: Fluorescence Spectramentioning

confidence: 99%

Interaction of water-soluble bridged porphyrin with DNA

et al. 2008

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A water-soluble porphyrin dimer (Por Dimer) containing eight positive charges, bridged by 4,49-dicarboxy-2,29-bipyridine, has been synthesized. With Meso-tetrakis(N-methyl-pyridium-4-yl)porphyrin (H 2 TMPyP) as the reference compound, the water-soluble porphyrin dimer was investigated for its interaction with DNA by absorption, fluorescence, and circular dichroism (CD) spectroscopy. The apparent affinity binding constant (K app 5 1.2 6 10 6 ) of Por Dimer binding to CT DNA was measured by a competition method with ethidium bromide (EB) (that of H 2 TMPyP was 6.9 6 10 6 ). The cleavage ability of Por Dimer to pBR322 plasmid DNA was studied by gel electrophoresis. The results suggest that the binding modes of Por Dimer were complex and involve both intercalation and outside binding.

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“…This can be ascribed to porphyrin aggregates, which are formed due to their binding to DNA when the concentration of the binding sites is lower than that of porphyrin molecules. When the concentration of the binding sites increases because of [DNA] addition, the aggregates relatively decompose in favor of the porphyrin-bound monomers [34].…”

Section: Fluorescence Spectroscopymentioning

confidence: 99%

Interaction of an Fe derivative of TMAP (Fe(TMAP)OAc) with DNA in comparison with free-base TMAP

Ghaderi

Bathaie

Saboury

et al. 2007

International Journal of Biological Macromolecules

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Aggregation of meso-tetrakis(4-N-methyl-pyridiniumyl) porphyrin in its free base, Fe(III) and Mn(III) forms due to the interaction with DNA in aqueous solutions: Optical absorption, fluorescence and light scattering studies

Cited by 55 publications

References 30 publications

Nitric oxide transfer from the NO-donor S-nitroso-N-acetylpenicillamine to monomers and dimers of water-soluble iron-porphyrins

Nitric oxide transfer from the NO-donor S-nitroso-N-acetylpenicillamine to monomers and dimers of water-soluble iron-porphyrins

Interaction of water-soluble bridged porphyrin with DNA

Interaction of an Fe derivative of TMAP (Fe(TMAP)OAc) with DNA in comparison with free-base TMAP

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