Agents Affecting Lipid Metabolism. XII. N,N'-Disubstituted Cyclohexane-1,4-bis(methylamines)<sup>1</sup>

Humber, Leslie G.

doi:10.1021/jm00336a043

Cited by 11 publications

(3 citation statements)

References 1 publication

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“…In order to provide a reliable means of distinguishing the LSc2ab virus and its subpassages from other type 1 viruses, whether attenuated or virulent, we have tested the use of two different antiviral substances in combination (1)(2). However, genetically determined markers of the LSc2ab virus (Sabin type 1 vaccine) that will distinguish it from all other type 1 strains, especially wild strains, are still being sought.…”

Section: Discussionmentioning

confidence: 99%

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Kotoulas

Recant

1966

Experimental Biology and Medicine

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Section: Discussionmentioning

confidence: 99%

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Kotoulas

Recant

1966

Experimental Biology and Medicine

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“…The agent trans-l,4-bis (2-chlorobenzylaminomethyl) cyclohexane dihydrochloride (AY-9944) ( 1 ) inhibits the biosynthesis of cholesterol by interfering with the enzymatic transformation of 7-dehydrochdesterol to cholesterol ( 2~) .…”

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confidence: 99%

Effect of the Cholesterol Biosynthesis Inhibitor AY-9944 on Serum Lipoproteins of Rats, Pigs and Dogs.

Hill¹,

Dvornik²

1966

Experimental Biology and Medicine

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Tomizawa and Halsey( 1) isolated an in-the reductive cleavage of the interchain disulin degrading enzyme from beef liver. sulfide bonds of insulin by virtue of H+ Tomizawa( 2) and Katzen and Stetten ( 3 ) transfer from reduced glutathione (GSH) and demonstrated that this liver enzyme catalyzes they proposed the name glutathione-insulin AM.5341.Subsequently, Katzen, Tietze and Stetten * Trainee (NIAMID) in Nutrition Grant ST1 transhydrogenase for the enzyme.

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“…Stimulation of fatty acid biosynthesis and concomitant depression of cholesterol biosynthesis have been reported in rat liver (Layne, Rudolph & Bessman, 1960;Foster & Bloom, 1963). trans-1,4 -Bis -(2-chlorobenzylaminomethyl)cyelohexane dihydrochloride (AY-9944) (Humber, 1964) given orally has been reported to inhibit the biosynthesis of cholesterol (Dvornlik, Kraml, Dubuc, Givner & Gaudry, 1963) by interfering with the enzymic conversion of 7-dehydrocholesterol into cholesterol (Kraml, Bagli & Dvornik, 1964). The agent increased the incorporation of labelled acetate into fatty acids (Givner & Dvornik, 1965) and affected the incorporation of labelled acyl and nitrogen base moieties into phospholipids (Hill, 1964).…”

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confidence: 99%

Effect of a cholesterol-biosynthesis inhibitor on the fatty acid composition of phospholipids in the serum and tissue of rats

Hill¹

1966

Biochemical Journal

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1. Changes produced by a cholesterol-biosynthesis inhibitor, trans-1,4-bis-(2-chlorobenzylaminomethyl)cyclohexane dihydrochloride (AY-9944), in the total fatty acids in the liver and brain, and in phospholipids in the serum, liver, heart, brain and lungs from male rats, have been studied. 2. Treatment with AY-9944 produced the following changes in the fatty acid composition: (a) a marked decrease in the percentage of linoleic acid and an increase in oleic acid in the total fatty acids in the liver; (b) in the serum, an overall decrease in the percentage of linoleic acid in neutral lipids and phospholipids; (c) an increased content of linoleic acid in the beta-acyl chain of phosphatidylcholines in the liver and in sphingomyelins in the brain and lungs; (d) an increased content of palmitic acid and oleic acid in the beta-acyl chain of phosphatidylcholine in the liver, heart and lungs; (e) an increased content of phosphatidylcholines and sphingomyelins, together with an increased percentage of saturated fatty acids in these phosphatides in the lungs. 3. Changes in the phosphatides and the production of foam cells in the lungs suggest that AY-9944 may be of use in the study of the alveolar membrane.

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Agents Affecting Lipid Metabolism. XII. N,N'-Disubstituted Cyclohexane-1,4-bis(methylamines)¹

Cited by 11 publications

References 1 publication

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Effect of the Cholesterol Biosynthesis Inhibitor AY-9944 on Serum Lipoproteins of Rats, Pigs and Dogs.

Effect of a cholesterol-biosynthesis inhibitor on the fatty acid composition of phospholipids in the serum and tissue of rats

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Agents Affecting Lipid Metabolism. XII. N,N'-Disubstituted Cyclohexane-1,4-bis(methylamines)1

Cited by 11 publications

References 1 publication

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Regeneration of Insulin from its Inactive Reduction Product in the Presence of Pancreatic Islets.

Effect of the Cholesterol Biosynthesis Inhibitor AY-9944 on Serum Lipoproteins of Rats, Pigs and Dogs.

Effect of a cholesterol-biosynthesis inhibitor on the fatty acid composition of phospholipids in the serum and tissue of rats

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Agents Affecting Lipid Metabolism. XII. N,N'-Disubstituted Cyclohexane-1,4-bis(methylamines)¹