2016
DOI: 10.21873/anticanres.11069
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Abstract: Abstract. An

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Cited by 105 publications
(74 citation statements)
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References 64 publications
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“…Mechanisms to repair the inevitable DNA damage associated with exposure to endogenous and exogenous agents are critical to the development and function of the nervous system as well as to protection against development of diseases, such as cancer (Cha & Yim, 2013; Curtin, 2012; Narciso et al, 2016; Smetana et al, 2016). Cancer and cancer treatment can initiate DNA damage and reduction in the effectiveness of some DNA repair mechanisms (Cha & Yim, 2013).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mechanisms to repair the inevitable DNA damage associated with exposure to endogenous and exogenous agents are critical to the development and function of the nervous system as well as to protection against development of diseases, such as cancer (Cha & Yim, 2013; Curtin, 2012; Narciso et al, 2016; Smetana et al, 2016). Cancer and cancer treatment can initiate DNA damage and reduction in the effectiveness of some DNA repair mechanisms (Cha & Yim, 2013).…”
Section: Discussionmentioning
confidence: 99%
“…Cancer and cancer treatment can initiate DNA damage and reduction in the effectiveness of some DNA repair mechanisms (Cha & Yim, 2013). In addition, there is reduced capacity of DNA repair mechanisms with advancing age, resulting in increased risk for cancer (Smetana et al, 2016). Mandelblatt et al (2013) propose a confluence of these factors, suggesting that cancer and its treatment may accelerate the effects of aging on neurons and oxidative stress and DNA repair pathways, which is reflected in accelerated cognitive aging in individuals with the disease.…”
Section: Discussionmentioning
confidence: 99%
“…The management of malignant diseases in elderly patients is becoming a global challenge as a result of the worldwide increasing life expectancy and this issue will turn into an even more compelling matter in the future . Over the last two decades, the average patients age at the first diagnosis of hepatocellular carcinoma (HCC) has progressively increased from 60 years in the mid‐nineties to 70 years more recently and it is expected to further raise .…”
Section: Introductionmentioning
confidence: 99%
“…Spermatogenesis is a complicated process to ultimately produce sperm, i.e., haploid cells to be fertilized with another haploid cells, i.e., oocytes, and involves dynamic processes, including meiosis of spermatocytes and drastic morphological changes of the germ line cells. Aging is associated with an increased risk of various diseases such as cancer as well as cardiovascular and neurodegenerative diseases [1][2][3], and in case of spermatogene s is, aging induce reduction of the sperm cell number and decrease in fertilit y [4,5]. Paternal aging also affects offspring's health and disease.…”
Section: Introductionmentioning
confidence: 99%