Ageing and gait variability--a population-based study of older people

Callisaya, Michele L.; Blizzard, Leigh; Schmidt, Michael D.; McGinley, Jennifer; Srikanth, Velandai

doi:10.1093/ageing/afp250

Cited by 258 publications

(215 citation statements)

References 31 publications

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“…Greater step width variability has been found with increasing age: older adults tend to control the CoM within their base of support by adjusting their step width to compensate for poor balance [7]. This may explain the increase in step width in the patients in our study when walking on the IFS.…”

Section: Kineticsmentioning

confidence: 51%

Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee

Noort

Esch

Steultjens

et al. 2011

Med Biol Eng Comput

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Osteoarthritis (OA) of the knee is associated with alterations in gait. As an alternative to force plates, instrumented force shoes (IFSs) can be used to measure ground reaction forces. This study evaluated the influence of IFS on gait pattern in patients with knee OA. Twenty patients with knee OA walked in a gait laboratory on IFS and control shoes (CSs). An optoelectronic system and force plate were used to perform 3D gait analyses. A comparison of temporalspatial gait parameters, kinematics, and kinetics was made between IFS and CS. Patients wearing IFS showed a decrease in walking velocity and cadence (8%), unchanged stride length, an increase in stance time (13%), stride time (11%) and step width (14%). No differences were found in knee adduction moment or knee kinematics. Small differences were found in foot and ankle kinematics (2-5°), knee transverse moments (5%), ankle frontal (3%) and sagittal moments (1%) and ground reaction force (1-6%). The gait of patients with knee OA was only mildly influenced by the IFS, due to increased shoe height and weight and a change in sole stiffness. The changes were small compared to normal variation and clinically relevant differences. Importantly, in OA patients no effect was found on the knee adduction moment.

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Section: Kineticsmentioning

confidence: 51%

Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee

Noort

Esch

Steultjens

et al. 2011

Med Biol Eng Comput

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“…Variability in human walking arises from many potential sources, including natural temporal dynamics of neuromotor control (da Costa, Batistão, & Rocha, 2013), pathologies of the neurological or musculoskeletal systems (Kaipust, Huisinga, Filipi, & Stergiou, 2012;Webster, Merory, & Wittwer, 2006), the effects of aging (Barak, Wagenaar, & Holt, 2006;Callisaya, Blizzard, Schmidt, McGinley, & Srikanth, 2010), shoe type (Jandová, Froňková, & Nováková, 2013) as well as variations in external environment (Chau, Young, & Redekop, 2005). one of the indicators that can assess the role of the preferred and non-preferred limbs, and age in stabilization during gait.…”

Section: Introductionmentioning

confidence: 99%

Effect of lower limb preference on variability of centre of pressure movement during gait

Svoboda

Bizovská²,

Kovačíková³

et al. 2015

Acta Gymnica

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“…Gait variability is a sensitive parameter, which in older humans was reported to predict cognitive decline (Brach et al 2008;Callisaya et al 2010;Cedervall et al 2014;Decker et al 2016;Gillain et al 2016;Herman et al 2005;Verghese et al 2002Verghese et al , 2007Verghese et al , 2008Wittwer et al 2013) and survival (Verlinden et al 2013) and associated with risk of falls (Verghese et al 2010). There is strong evidence that vascular pathologies promote gait variability.…”

Section: Discussionmentioning

confidence: 99%

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

et al. 2017

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There is correlative evidence that impaired cerebral blood flow (CBF) regulation, in addition to promoting cognitive impairment, is also associated with alterations in gait and development of falls in elderly people. CBF is adjusted to neuronal activity via neurovascular coupling (NVC) and this mechanism becomes progressively impaired with age. To establish a direct cause-andeffect relationship between impaired NVC and gait abnormalities, we induced neurovascular uncoupling pharmacologically in young C57BL/6 mice by inhibiting the synthesis of vasodilator mediators involved in NVC. Treatment of mice with the epoxygenase inhibitor MSPPOH, the NO synthase inhibitor L-NAME, and the COX inhibitor indomethacin significantly decreased NVC mimicking the aging phenotype. Pharmacologically induced neurovascular uncoupling significantly decreased the dynamic gait parameter duty cycle, altered footfall patterns, and significantly increased phase dispersion, indicating impaired interlimb coordination. Impaired NVC also tended to increase gait variability. Thus, selective experimental disruption of NVC causes subclinical gait abnormalities, supporting the importance of CBF in both cognitive function and gait regulation.

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Ageing and gait variability--a population-based study of older people

Cited by 258 publications

References 31 publications

Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee

Influence of the instrumented force shoe on gait pattern in patients with osteoarthritis of the knee

Effect of lower limb preference on variability of centre of pressure movement during gait

Pharmacologically induced impairment of neurovascular coupling responses alters gait coordination in mice

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