volume 10, issue 6, P1356-1365 2018
DOI: 10.18632/aging.101472
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Chi Yang, Ying Jiao, Bing Wei, Zeyi Yang, Jin-Fu Wu, Jorgen Jensen, Wei-Horng Jean, Chih-Yang Huang, Chia-Hua Kuo

Abstract: It remains unclear how exercise, as an entropic event, brings benefit against human aging. Here we examined longitudinal changes of p16Ink4a+ senescent cells in skeletal muscle of young men (aged 22.5±1.7 y) before and after resistance exercise (0 h and 48 h) with multiple biopsies at two different protein availabilities: low protein (14%) and isocaloric high protein (44%) supplemented conditions. Immunohistochemistry analysis of muscle cross-sections using p16Ink4a and CD34 antibodies confirmed that the detec…

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