Age-specific reference ranges of prostate-specific antigen in the elderly of Amirkola: A population-based study

Reza, Hosseini Seyed; Zabihi, Ali; Habibian, Tara; Bijani, Ali

doi:10.1016/j.ajur.2020.03.001

Cited by 10 publications

(7 citation statements)

References 25 publications

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“…Both in rural and in urban areas, PSA level increases with age, which agrees with what has been published by other authors [21]. In our study, men from rural areas had higher PSA comparing with men of urban area, which is a new finding since there are no studies that compare PSA levels in men who live in rural area compared to men who live in urban area in our environment.…”

Section: Diagnosis Of Prostate Diseasesupporting

confidence: 92%

Impact of social and medical factors on routine clinical practice in prostate exams of asymptomatic males

Bravo-Grande¹,

Padilla‐Fernández²,

Flores-Fraile³

et al. 2021

JOMH

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Objectives: To examine routine clinical practice in prostate health exams in asymptomatic males, and to identify which factors inﬂuence it. Materials and methods: Multicentre cross-sectional study in 1068 asymptomatic men aged 51-72. Groups: GA (n = 518): urban areas; GB (n = 550): rural areas. GA subgroups: GA1 (n = 364): prostate speciﬁc antigen (PSA) measured; GA2 (n = 154): PSA not measured. GB subgroups: GB1 (n = 346): PSA measured; GB2 (n = 204): PSA not measured. Variables: age, body mass index (BMI), digital rectal examination (DRE), PSA, prostate diagnosis, eating habits, physical exercise, marital status, number of children, occupational status, working hours, concomitant diseases and conditions, family history, attending physician. Descriptive statistics, Student's t-test, chi-square test, Fisher's exact test, ANOVA, Pearson and Spearman correlations were used. Results: Mean age 62.3 years (standard deviation: SD 5.12). Age in GA (60.89, SD 5.53) was lower than in GB (65.10, SD 5.03); age was higher in GA1 (61.22, SD 5.49) than in GA2 (59.04, SD 5.37). There was no difference in BMI between GA and GB. DRE: No exams were performed without prior PSA. No DRE were performed in GA; 11 (3.18%) were performed in GB1. GA1: 53 had PSA > 4 ng/mL, of whom 28 had no prostate disease, 17 had benign prostatic hyperplasia (BPH) and 8 had prostate cancer (PCa). PCa prevalence in men with PSA > 4 ng/mL was 9.24% in GA and 5.19% in GB. GA1: higher PSA was correlated with lower BMI, lower age, higher occupational status, and morning shifts; lower PSA was correlated with higher alcohol consumption; older patients worked shifts and consumed more alcohol; men with higher occupational status consumed less alcohol; more men were married in GA1 (n = 343, [94.23%]) than in GA2 (n = 100, [64.93%]). In GA1, there were more non-smoking men (n = 291, [80.11%]) and men who smoked < 5 cigarettes/day (n = 23, [6.37%]), 6-10 cigarettes/day (n = 15, [4.05%]), and 11.20 cigarettes/day (n = 27, [7.33%]) than in GA2. Older men and men with higher occupational status consumed fewer cigarettes. Men who worked rotating shifts smoked more. There was no relationship between smoking and PSA level. There were more university-educated men in GA (n = 309, [59.65%]) than in GB (n = 110, [20%]). More men did not take physical exercise in GA2 (n = 49, [31.81%]) than in GA1 (n = 75, [23.90%]). GB1: PSA > 4 ng/mL in 89 patients, of whom 32 had PCa; younger men had higher PSA. PSA was higher in GB1 (mean 18.95 ng/mL, SD 12.93) than in GA1 (mean 1.61, SD 1.63). Men in GB ate more fast food than GA, with no difference between GA1 and GA2, or between GB1 and GB2. In GA there was variability in approach among the attending physicians; in GB there was no variability among attending physicians. Conclusions: PSA tests are routinely given to 70.27% of asymptomatic men who consult a doctor in urban environments and to 62.09% of men in rural environments. In urban areas, the decision is affected by the preferences of the attending physician and by whether the patient is married. Occupational category, working hours and educational level have no impact. The decision to undergo a prostate health exam is associated with healthy habits such as physical exercise. No relationship was found between prostate disorders in asymptomatic men and high BMI, dyslipidemia or diet.

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Section: Diagnosis Of Prostate Diseasesupporting

confidence: 92%

Impact of social and medical factors on routine clinical practice in prostate exams of asymptomatic males

Bravo-Grande¹,

Padilla‐Fernández²,

Flores-Fraile³

et al. 2021

JOMH

View full text Add to dashboard Cite

show abstract

“…Prostatespecific antigen level is correlated with age and as age increases, PSA level also becomes higher. 20 This relationship can be explained by the fact that there is age related increase in the prevalence of benign prostatic enlargement. 21 Our study found that the mean PSA level increased with age )3.41±4.67 ng/dL(, especially in those aged 80 years and older.…”

Section: Resultsmentioning

confidence: 99%

Association between body mass index and hemoglobin A1c with serum prostate-specific antigen level

Alhamdan,

Alsulaiman,

Alsabti

et al. 2023

SMJ

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“…We are conscious of different limitations of our study. First, the retrospective nature of our work, associated with the relatively limited sample size, does not permit drawing certain conclusions; secondly, the absence of a stratified PSA according to the age of patients, which, if one on side could have been an interesting aspect of our work, could have further limited the recruited sample size in smaller groups; thirdly, we assumed as a normal PSA a mean value <4 ng/mL which could not be associated with older patients [49][50][51][52][53]. We aim to evaluate these aspects and resolve these pitfalls in the next study.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign

Crocetto

Barone

D’Aguanno

et al. 2023

JCM

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Prostate cancer (PCa) is the most common non-cutaneous malignancy in men worldwide, and it represents the fifth leading cause of death. It has long been recognized that dietary habits can impact prostate health and improve the benefits of traditional medical care. The activity of novel agents on prostate health is routinely assessed by measuring changes in serum prostate-specific antigen (PSA) levels. Recent studies hypothesized that vitamin D supplementation reduces circulating androgen levels and PSA secretion, inhibits cell growth of the hormone-sensitive PCa cell lines, counteracts neoangiogenesis and improves apoptosis. However, the results are conflicting and inconsistent. Furthermore, the use of vitamin D in PCa treatments has not achieved consistently positive results to date. In order to assess the existence of a correlation between the PSA and 25(OH)vitamin D levels as widely hypothesized in the literature, we analyzed the serum PSA and 25(OH)vitamin D concentration on a cohort of one hundred patients joining a PCa screening campaign. Additionally, we performed medical and pharmacological anamnesis and analyzed lifestyle, as sport practice and eating habits, by administering a questionnaire on family history. Although several studies suggested a protective role of vitamin D in PCa onset prevention and progression, our preliminary results revealed a clear absence of correlation between the serum vitamin D and PSA concentration levels, suggesting that vitamin D has no impact on PCa risk. Further investigations enrolling a huge number of patients are needed with particular attention to vitamin D supplementation, calcium intake, solar radiation that influences vitamin D metabolism and other potential indicators of health to confirm the absence of correlation observed in our study.

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Age-specific reference ranges of prostate-specific antigen in the elderly of Amirkola: A population-based study

Cited by 10 publications

References 25 publications

Impact of social and medical factors on routine clinical practice in prostate exams of asymptomatic males

Impact of social and medical factors on routine clinical practice in prostate exams of asymptomatic males

Association between body mass index and hemoglobin A1c with serum prostate-specific antigen level

Vitamin D, a Regulator of Androgen Levels, Is Not Correlated to PSA Serum Levels in a Cohort of the Middle Italy Region Participating to a Prostate Cancer Screening Campaign

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