Age-Specific Prevalence of Human Papillomavirus Infection in Males: A Global Review

Smith, Jennifer S.; Gilbert, Paul A.; Melendy, Amy; Rana, Rashida K.; Pimenta, Jeanne M.

doi:10.1016/j.jadohealth.2011.03.010

Cited by 135 publications

(125 citation statements)

References 91 publications

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“…Fifteen genotypes are clearly linked to the development of adenocarcinoma and squamous cell carcinoma of the cervix and therefore rank as high-risk: HPV-16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -68, -73, and -82. Twelve genotypes are either not potentially oncogenic, or not involved in the development of cervical cancer, and are considered low-risk: HPV-6, -11, -40, -42, -43, -44, -54, -61, -70, -72, -81, and CP6108 (1,2) Increasing evidence suggests that multiple factors contribute to the development of cervical cancer, including genetic susceptibility or host genome, HPV variants, coinfection of HPV and other agents, and life-style factors (3). Although all genotypes of HPV correlate with cervical cancers, HPV-16 and HPV-18 infection accounts for about 70% of all cases.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and genotype distribution of human papillomavirus among Hakka women in China

Zeng¹,

Yan²,

Huang³

et al. 2016

Ann. Transl. Med.

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Background: Human papillomavirus (HPV) infection is the primary risk factor for cervical cancer. HPV genotypes are associated with varying degrees of pathogenicity. To better formulate strategies for cervical cancer prevention, we investigated the population-specific distribution of HPV genotypes, including those with high carcinogenicity. Results: Risk stratification based on genotypes indicated that the prevalence of overall, high-risk, and low-risk HPV infections was 12.27%, 14.20%, and 0.79%, respectively. Of the 1,003 women positively infected, 82.75%were infected with a single HPV type; 17.25% were infected with ≥2 types. Analysis revealed a U-shaped curve in HPV prevalence that correlated with age group, with peaks at ages 18-24 y (22.03%) and 60-65 y (25%). The most frequently detected HPV genotype was HPV-52 (26.81%), and then HPV-16 (17.54%), HPV-58 (14.25%), HPV-18 (10.16%), HPV-68 (8.27%), HPV-39 (5.68%), and HPV-51 (5.38%).Conclusions: HPV-52 is the most prevalent genotype infecting Hakka women. Therefore, vaccination against HPV-52 is imperative. The prevalence of HPV infection is highest in the younger (18-24 y) and older (60-65 y) age groups, indicating that screening for HPV in Hakka women should be performed early and maintained in the elderly.

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Section: Introductionmentioning

confidence: 99%

Prevalence and genotype distribution of human papillomavirus among Hakka women in China

Zeng¹,

Yan²,

Huang³

et al. 2016

Ann. Transl. Med.

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“…More insight into the associations between HPV infection at various anatomic sites, HIV infection, and seroresponse is crucial to interpret results from serosurveillance, which can, for example, be used to monitor HPV prevention strategies. As men who have sex with men (MSM), and especially HIVinfected MSM, are at increased risk for HPV infection (15) and HPV-related diseases (16,17), understanding these issues among MSM is important. In this study, we aimed to assess type-specific HPV seroconversion following anal and penile HPV infection in HIV-negative and HIVinfected MSM.…”

Section: Introductionmentioning

confidence: 99%

HPV Seroconversion Following Anal and Penile HPV Infection in HIV-Negative and HIV-Infected MSM

Mooij

Landén

Klis

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We assessed human papillomavirus (HPV) seroconversion following anal and penile HPV infection in HIV-negative and HIV-infected men who have sex with men (MSM).Methods: MSM aged !18 years were recruited in Amsterdam, the Netherlands (2010-2011), and followed up semiannually. Antibodies against 7 high-risk HPV types in baseline and 12-month serum samples were tested using a multiplex immunoassay. Baseline, 6-, and 12-month anal and penile samples were tested for HPV DNA using the SPF 10 -PCR DEIA/LiPA 25 system. Statistical analyses were performed using logistic regression with generalized estimating equations.Results: Of 644 MSM included in the analysis, 245 (38%) were HIV-infected. Median age was 38 years for HIV-negative and 47 years for HIV-infected MSM (P < 0.001). Seroconversion against !1 of the 7 HPV types was observed in 74 of 396 (19%) HIV-negative and 52 of 223 (23%) HIV-infected MSM at risk (P ¼ 0.2). Incident [adjusted OR (aOR) 2.0; 95% confidence interval (CI), 1.1-3.4] and persistent (aOR 3.7; 95% CI, 1.5-9.5) anal HPV infections were independently associated with type-specific seroconversion in HIV-negative MSM. In HIVinfected MSM, there was a nonsignificant positive association between penile HPV infection at any time point and seroconversion (aOR 1.7; 95% CI, 0.9-3.2).Conclusions: Incident or persistent anal HPV infection was an independent determinant of seroconversion in HIV-negative MSM.Impact: Our data support that seroresponse may vary per anatomic site and that persistent HPV infections are more likely to elicit a detectable humoral immune response. Cancer Epidemiol Biomarkers Prev; 23(11); 2455-61. Ó2014 AACR.

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“…Most international research has focused on HPV and HPV/HIV coinfections in women, with less attention to anal HPV infection in men, particularly MSM. 12,13 Studies from China and Brazil have documented a high prevalence of HIV/HPV coinfection among MSM. 14,15 Studies of Brazilian MSM have also demonstrated an association between HPV, anal squamous epithelial dysplasia, and HIV infection.…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

Quinn

Salvatierra

Solari

et al. 2012

AIDS Research and Human Retroviruses

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Human papillomavirus (HPV) infection among men who have sex with men (MSM) is the primary risk factor for anal cancer. Of 105 Peruvian MSM examined, 77.1% were infected with HPV; of these 79.0% were coinfected with two or more types and 47.3% were infected by a carcinogenic type. HPV types 53, 6, 16, and 58 were the most frequent HPV infections detected. High-risk HPV type infection was associated with sex work, HIV status, and having rectal chlamydial or gonorrheal infection. These findings support broadening HPV vaccine coverage and increasing surveillance for the development of cancer in MSM infected with HPV.

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Age-Specific Prevalence of Human Papillomavirus Infection in Males: A Global Review

Cited by 135 publications

References 91 publications

Prevalence and genotype distribution of human papillomavirus among Hakka women in China

Prevalence and genotype distribution of human papillomavirus among Hakka women in China

HPV Seroconversion Following Anal and Penile HPV Infection in HIV-Negative and HIV-Infected MSM

Human Papillomavirus Infection in Men Who Have Sex with Men in Lima, Peru

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