Age-Specific Prevalence of and Risk Factors for Anal Human Papillomavirus (HPV) among Men Who Have Sex with Women and Men Who Have Sex with Men: The HPV in Men (HIM) Study

Nyitray, Alan G.; Silva, Roberto J. Carvalho da; Baggio, Maria Luiza; Lu, Binfeng; Smith, Danélle; Abrahamsen, Martha; Papenfuss, Mary; Villa, Luisa L.; Lazcano‐Ponce, Eduardo; Giuliano, Anna R.

doi:10.1093/infdis/jiq021

Cited by 188 publications

(180 citation statements)

References 37 publications

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“…In the HPV Infection in Men (HIM) study, a large ongoing prospective study of heterosexual men recruited from the general population, universities and healthcare settings in Brazil, Mexico and USA, the baseline prevalence of genital any-type HPV was 53.1% among 3326 healthy heterosexual males aged 18-70 years [36]. In the same study, anal canal any-type HPV prevalence was 12.2% among 1305 men who have sex with women and 47.2% among 176 MSM, with MSM much more likely to test positive for multiple types [37]. In addition, genital HPV prevalence appears to be high even in young, relatively sexually inexperienced men.…”

Section: Current Male Vaccination Implementation In Public Health Promentioning

confidence: 84%

How to best measure the effectiveness of male human papillomavirus vaccine programmes?

Garland

Machalek

Cornall

et al. 2015

Clinical Microbiology and Infection

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In many countries now, vaccination of young adolescent girls with prophylactic human papillomavirus (HPV) vaccines has been rolled out as a public health programme. In countries where coverage has been high, this has led to dramatic reductions in cervical high-grade precancerous lesions, as well as genital warts. A reduction in circulating vaccine-related HPV types has also been demonstrated. With the introduction of gender-neutral approaches incorporating universal vaccination of pre-adolescent boys in some countries, implementation of post-vaccine monitoring will be critical to evaluate the incremental impact of male vaccination. In contrast to cervical screening programmes, population-wide screening for HPV infection or related disease in males is not recommended; hence real-time monitoring of HPV vaccine effectiveness in males will require dedicated surveillance strategies. Monitoring the prevalence of circulating genital HPV types using a sentinel surveillance model could offer a good surrogate marker of early vaccine effectiveness in males. However, such an approach requires careful consideration of the most appropriate anatomical sites from which to collect specimens, the best sampling methods and the most sensitive assays to use. Additionally, in assessing an accurate measure of the impact of HPV vaccination in the male population, the effect of herd protection will need to be assessed, as most male programmes will commence in the setting of established female programmes. This poses an interesting epidemiological challenge.

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Section: Current Male Vaccination Implementation In Public Health Promentioning

confidence: 84%

How to best measure the effectiveness of male human papillomavirus vaccine programmes?

Garland

Machalek

Cornall

et al. 2015

Clinical Microbiology and Infection

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show abstract

“…Men who have sex with men (MSM) have a high risk for human immunodeficiency virus (HIV), and present HPV infections in the anus much more than men who have sex with women (MSW). Some previous studies demonstrated that anal HPV prevalence rates were 4e10 times higher in MSM compared to MSW [1,2]. In particular, higher anal HPV infectious rates ranging from 47% to 96% have been reported in HIV-infected MSM [3e9], which are higher than ones reported in HIV-negative MSM [10,11].…”

Section: Introductionmentioning

confidence: 95%

Human papillomavirus prevalence in the anus and urine among HIV-infected Japanese men who have sex with men

Yaegashi

Shigehara

Itoda³

et al. 2017

Journal of Infection and Chemotherapy

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Keywords:Human papillomavirus Human immunodeficiency virus Men who have sex with men Anal sample Urine a b s t r a c tBackground: The present study investigated human papillomavirus (HPV) prevalence in anal and urine samples, and evaluated cytological findings among human immunodeficiency virus (HIV)-infected Japanese men who have sex with men (MSM). Methods: A total of 148 patients were enrolled. Anal and urine samples were collected from each participant, and a HPV-DNA test and genotyping were performed using flow-through hybridization. In addition, anal cytology was evaluated based on Papanicolaou staining. Questionnaires regarding lifestyle habits and sexual behavior were obtained. Results:The b-globin gene was positive in 131 (88.5%) anal samples and 139 (94.0%) urine samples. Among the b-globin-positive samples, the HPV prevalence in anal and urine samples was 80.9% and 30.9%, respectively. High-risk HPV (HR-HPV) was detected in 57.3% of anal samples and 20.9% of urine samples. Among 122 adequate cytological samples, anal cytological abnormalities were observed in 99 cases (81.1%). Anal cytological tests revealed that atypical squamous cells of an undetermined significance (ASCUS) were detected in 57 (46.7%) patients, followed by low-grade squamous intraepithelial lesions (SIL) in 35 (28.7%), high-grade SIL in five (4.1%), and atypical squamous cells cannot exclude highgrade SIL (ASC-H) in two (1.6%), respectively. The nadir counts of CD4-positive T-lymphocyte less than 200 mL and anal HR-HPV infection were independent risk factors for anal cytological atypia over ASC-H. Conclusions:The present study demonstrated high HPV prevalence in the anus and urine, and showed a high incidence of anal cytological atypia associated with HR-HPV infections among HIV-infected MSM patients.

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“…Además, es importante destacar las diferencias en la positividad para VPH entre las muestras perianales y anales de hombres heterosexuales y HSH, donde las muestras de estas zonas en HSH fueron 32,8% positivas, una proporción dos veces superior a la de hombres heterosexuales en el mismo estudio 46 . A su vez, en un estudio reciente se han determinado prevalencias de 12,2% entre heterosexuales y 47,2% entre HSH para la misma zona 47 . También se ha descrito la prevalencia de más de un tipo de VPH infectando un mismo individuo.…”

Section: Tipos De Muestras Para La Detección De Vph En Hombresunclassified

Diagnóstico de la infección por virus papiloma humano en el hombre

Silva

León

Brebi-Mieville

et al. 2013

Rev. chil. infectol.

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Age-Specific Prevalence of and Risk Factors for Anal Human Papillomavirus (HPV) among Men Who Have Sex with Women and Men Who Have Sex with Men: The HPV in Men (HIM) Study

Abstract: Number of sex partners was associated with anal HPV infection in both MSW and MSM. Anal HPV infection in men may be mediated by age, duration of sexual relationship, and condom use.

Cited by 188 publications

References 37 publications

How to best measure the effectiveness of male human papillomavirus vaccine programmes?

How to best measure the effectiveness of male human papillomavirus vaccine programmes?

Human papillomavirus prevalence in the anus and urine among HIV-infected Japanese men who have sex with men

Diagnóstico de la infección por virus papiloma humano en el hombre

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