Age-specific and seasonal deposition of outdoor and indoor particulate matter in human respiratory tract

Manojkumar, N.; Srimuruganandam, B.

doi:10.1016/j.apr.2021.101298

Cited by 15 publications

(9 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to ICRP [29] , the respiratory tract clearance model consists of 13 compartments. The retained dose of particles in each compartment j and the dose to the esophagus, lymph nodes, and blood was estimated by Equation ( 12), while Equation ( 13) was used for rapidly and slowly dissolving particles [22] :…”

Section: Clearancementioning

confidence: 99%

“…Thus, the majority of the deposited particles in the human respiratory tract were transferred to the esophagus (51%), a finding that is associated with the high deposited dose in the ET region due to the high contribution of coarse particles to PM 10 . The clearance of PM 10 depends on the deposition sites: the deposited particles in the ET region are transferred mainly to the GI tract (esophagus) via mucociliary clearance, while the deposited particles in the TB and AI regions require more time to transfer to the ET2 region and are swallowed to the GI tract, and hence they remain in the respiratory tract and absorbed to the blood [22] . Tomasi et al asserted that mucociliary clearance is a fast process for PM 10 , while for particles with a diameter less than 3 μm the clearance is less efficient [45] .…”

Section: Clearance Of Deposited Pm 10mentioning

confidence: 99%

“…Thompson et al asserted that 40%-50% of the total mass is retained in the human respiratory tract, which is slightly higher than what was found in the current study (38%) [46] . The present model (ExDoM2) has been used in other studies [22,47] to assess the clearance of PM. Specifically, Chalvatzaki et al applied the model to data from three European cities and found that the dose to the esophagus was equal to 44, 84, and 172 μg for Kuopio, Athens, and Lisbon, respectively [22] .…”

Section: Clearance Of Deposited Pm 10mentioning

confidence: 99%

“…The present model (ExDoM2) has been used in other studies [22,47] to assess the clearance of PM. Specifically, Chalvatzaki et al applied the model to data from three European cities and found that the dose to the esophagus was equal to 44, 84, and 172 μg for Kuopio, Athens, and Lisbon, respectively [22] . Therefore, the dose to esophagus for all three cities was lower in comparison to the current study.…”

Section: Clearance Of Deposited Pm 10mentioning

confidence: 99%

“…Additionally, Vu et al calculated the dose of traffic-generated particles (13-560 nm) and found that the dose rate of outdoor particles at a traffic site (Bologna, Italy) was 10 10 particles/h with the majority of particles deposited in the AI region [8] . Regarding PM, Chalvatzaki et al found that the deposited mass dose was higher in the ET region, and 75% of the deposited mass dose in the ET region was associated with coarse particles [22] . In addition, Manojkumar and Srimuruganandam found that the deposition of PM 10 at an outdoor traffic site was higher than that at an outdoor residential site [23] .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Regional deposited dose in the human respiratory tract using different particulate metrics

Chalvatzaki¹,

Chatoutsidou²,

Lazaridis³

2022

J Environ Expo Assess

View full text Add to dashboard Cite

The objective of the current study was to calculate the deposited dose rate in the human respiratory tract arising from particle number (PN) and particle mass (PM) measurements. A main objective was the investigation of deposition pattern and characteristics of the two metrics in the human respiratory tract. The dose rate was estimated for residents at a suburban background location (Chania, Greece). The total dose rate showed two peaks, one in the morning (1.6 × 109 particles/h at 7:00-8:00) and the other one at night (2.1 × 109 particles/h at 21:00-22:00), during the warm period, while the cold period showed two peaks, morning (2.0 × 109 particles/h at 9:00-10:00) and afternoon (3.6 × 109 particles/h at 18:00-19:00). The peaks during the warm period were associated with traffic emissions, whereas the peaks during the cold period were associated with both heating and traffic emissions. A higher dose rate of PN10 was found in the alveolar region while for PM10 it was found in the extrathoracic region. These findings are linked with increased contribution of ultrafine and coarse particles to PN10 (65%-78% and 54%-62% for cold and warm periods, respectively) and PM10 (63% and 55% for cold and warm periods, respectively) concentrations, respectively. The current study showed the importance to use both number and mass aerosol metrics for determining the human exposure and regional dose and their related health effects. The novelty of the current study is the simultaneous measurements of the two particles metrics and the full particle size distributions to make accurate estimates of regional deposited dose.

show abstract

Section: Clearancementioning

confidence: 99%

Section: Clearance Of Deposited Pm 10mentioning

confidence: 99%