Jaime Fernández-Barrera, Isabel Correas, Miguel A. Alonso
Microtubules (MTs) are highly dynamic cytoskeletal polymers that are involved in a wide range of cellular processes such as cell polarity, morphogenesis and vesicular transport. The bulk of cytoskeletal MTs last only a few minutes but there is an MT subset with a much longer duration. This long-lived subset accumulates a number of covalent posttranslational modifications such as acetylation. The acetylation in the Lys 40 residue of α-tubulin, which occurs in the MT lumen, weakens lateral inter-protofilament i…
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