volume 9, issue 12, P2489-2503 2017
DOI: 10.18632/aging.101333
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Sarah E. Harris, Valentina Riggio, Louise Evenden, Tamara Gilchrist, Sarah McCafferty, Lee Murphy, Nicola Wrobel, Adele M. Taylor, Janie Corley, Alison Pattie, Simon R. Cox, Carmen Martin-Ruiz, James Prendergast, John M. Starr et al.

Abstract: Gene expression is influenced by both genetic variants and the environment. As individuals age, changes in gene expression may be associated with decline in physical and cognitive abilities. We measured transcriptome-wide expression levels in lymphoblastoid cell lines derived from members of the Lothian Birth Cohort 1936 at mean ages 70 and 76 years. Changes in gene expression levels were identified for 1,741 transcripts in 434 individuals. Gene Ontology enrichment analysis indicated an enrichment of biologica…

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