Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response

Fernández, Macarena; Fabio, María Carolina; Miranda-Morales, Roberto Sebastián; Virgolini, Miriam Beatríz; Giovanni, Laura Noemi de; Hansen, Cristian; Wille-Bille, Aranza; Nizhnikov, Michael E.; Spear, Linda P.; Pautassi, Ricardo Marcos

doi:10.1016/j.alcohol.2015.11.009

Cited by 27 publications

(20 citation statements)

References 50 publications

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“…It is noteworthy, however, that compared to adults, adolescents have been described to be more reactive to stress and to stress-ethanol interactions. In a recent study we found significantly greater ethanol intake time in adolescent, but not in adult, rats given chronic restraint stress ( Fernandez et al, 2016 ).…”

Section: Discussionmentioning

confidence: 78%

Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood

Berardo

Fabio

Pautassi

2016

Front. Behav. Neurosci.

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This study analyzed ethanol intake in male and female Wistar rats exposed to maternal separation (MS) during infancy (postnatal days 1–21, PD1–21) and environmental enrichment (EE) during adolescence (PD 21–42). Previous work revealed that MS enhances ethanol consumption during adulthood. It is still unknown if a similar effect is found during adolescence. Several studies, in turn, have revealed that EE reverses stress experiences, and reduces ethanol consumption and reinforcement; although others reported greater ethanol intake after EE. The interactive effects between these treatments upon ethanol’s effects and intake have yet to be explored. We assessed chronic ethanol intake and preference (12 two-bottle daily sessions, spread across 30 days, 1st session on PD46) in rats exposed to MS and EE. The main finding was that male – but not female – rats that had been exposed to EE consumed more ethanol than controls given standard housing, an effect that was not affected by MS. Subsequent experiments assessed several factors associated with heightened ethanol consumption in males exposed to MS and EE; namely taste aversive conditioning and hypnotic-sedative consequences of ethanol. We also measured anxiety response in the light-dark box and in the elevated plus maze tests; and exploratory patterns of novel stimuli and behaviors indicative of risk assessment and risk-taking, via a modified version of the concentric square field (CSF) test. Aversive conditioning, hypnosis and sleep time were similar in males exposed or not to EE. EE males, however, exhibited heightened exploration of novel stimuli and greater risk taking behaviors in the CSF test. It is likely that the promoting effect of EE upon ethanol intake was due to these effects upon exploratory and risk-taking behaviors.

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Section: Discussionmentioning

confidence: 78%

Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood

Berardo

Fabio

Pautassi

2016

Front. Behav. Neurosci.

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“…Intriguingly, 5 days of restraint-induced stress exacerbated free choice ethanol drinking in adolescent, but not adult rats. Furthermore, adult rats had a greater level of ethanol sedation in comparison adolescents rats, but only the adolescent animals exhibited ethanol-induced motor stimulation (Acevedo et al, 2013; Fernández et al, 2016), suggesting that stress modulates the effects of ethanol in an age-dependent manner. Interestingly, Pautassi’s group further reported that female rats that show high baseline anxiety levels displayed higher ethanol intake as compared to female rats with average levels of anxiety.…”

Section: Contributions From Latin Americamentioning

confidence: 99%

“…In a subsequent set of papers, Dr. Pautassi’s group compared the effects of acute or repeated restraint-induced stress during adolescence and adulthood on ethanol consumption in male and female rats (Acevedo et al, 2013, 2016; Fernández et al, 2016; Wille-Bille et al, 2017). The authors found no effects of acute restraint stress on spontaneous or ethanol-induced locomotion at either age, whereas adult rats showed an enhanced and long-lasting sedative effect due to ethanol exposure as compared to adolescent rats (Acevedo et al, 2013).…”

Section: Contributions From Latin Americamentioning

confidence: 99%

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience

et al. 2018

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Drug addiction is a chronic neuropsychiatric disorder that escalates from an initial exposure to drugs of abuse, such as cocaine, cannabis, or heroin, to compulsive drug-seeking and intake, reduced ability to inhibit craving-induced behaviors, and repeated cycles of abstinence and relapse. It is well-known that chronic changes in the brain’s reward system play an important role in the neurobiology of addiction. Notably, environmental factors such as acute or chronic stress affect this system, and increase the risk for drug consumption and relapse. Indeed, the HPA axis, the autonomic nervous system, and the extended amygdala, among other brain stress systems, interact with the brain’s reward circuit involved in addictive behaviors. There has been a growing interest in studying the molecular, cellular, and behavioral mechanisms of stress and addiction in Latin-America over the last decade. Nonetheless, these contributions may not be as strongly acknowledged by the broad scientific audience as studies coming from developed countries. In this review, we compile for the first time a series of studies conducted by Latin American-based neuroscientists, who have devoted their careers to studying the interaction between stress and addiction, from a neurobiological and clinical perspective. Specific contributions about this interaction include the study of CRF receptors in the lateral septum, investigations on the neural mechanisms of cross-sensitization for psychostimulants and ethanol, the identification of the Wnt/β-catenin pathway as a critical neural substrate for stress and addiction, and the emergence of the cannabinoid system as a promising therapeutic target. We highlight animal and human studies, including for instance, reports coming from Latin American laboratories on single nucleotide polymorphisms in stress-related genes and potential biomarkers of vulnerability to addiction, that aim to bridge the knowledge from basic science to clinical research.

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“…This technique allows collecting information about neurochemicals in the extracellular space by means of the implantation of a semipermeable probe (300-mm outer diameter). Indeed, after over 30 years, brain microdialysis still represents a very powerful approach whose pros and cons have been elegantly and thoroughly discussed in seminal reviews (Di Chiara, Tanda, & Carboni, 1996;Kennedy, 2013;Rocchitta & Serra, 2013). In particular, brain microdialysis has proven to be slightly invasive and characterized by a relatively low temporal resolution, and characterized by requiring an association with an analytical instrumentation for the analysis of collected samples (Rocchitta & Serra, 2013).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous wireless and high-resolution detection of nucleus accumbens shell ethanol concentrations and free motion of rats upon voluntary ethanol intake

Rocchitta

Peana

Bazzu

et al. 2019

Alcohol

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Age-related effects of chronic restraint stress on ethanol drinking, ethanol-induced sedation, and on basal and stress-induced anxiety response

Cited by 27 publications

References 50 publications

Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood

Post-weaning Environmental Enrichment, But Not Chronic Maternal Isolation, Enhanced Ethanol Intake during Periadolescence and Early Adulthood

Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience

Simultaneous wireless and high-resolution detection of nucleus accumbens shell ethanol concentrations and free motion of rats upon voluntary ethanol intake

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