2016
DOI: 10.18632/aging.100879
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Abstract: Age-related loss of muscle mass and strength can be accelerated by impaired recovery of muscle mass following a transient atrophic stimulus. The aim of this study was to identify the mechanisms underlying the attenuated recovery of muscle mass and strength in old rats following disuse-induced atrophy. Adult (9 month) and old (29 month) male F344BN rats underwent hindlimb unloading (HU) followed by reloading. HU induced significant atrophy of the hindlimb muscles in both adult (17-38%) and old (8-29%) rats, but… Show more

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Cited by 142 publications
(208 citation statements)
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References 66 publications
(77 reference statements)
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“…The dissociation of muscle mass and muscle strength found in the present study has been previously described in various conditions, including sarcopenia (Baehr et al 2016; Goodpaster et al 2006; Metter et al 1999). The potential physiologic explanations for this dissociation are many, including neuropathies, neuromuscular junction injury, and excitation-contraction uncoupling among others.…”
Section: Discussionsupporting
confidence: 86%
“…The dissociation of muscle mass and muscle strength found in the present study has been previously described in various conditions, including sarcopenia (Baehr et al 2016; Goodpaster et al 2006; Metter et al 1999). The potential physiologic explanations for this dissociation are many, including neuropathies, neuromuscular junction injury, and excitation-contraction uncoupling among others.…”
Section: Discussionsupporting
confidence: 86%
“…Our laboratory and others have shown that disuse-induced atrophy is less in old muscle relative to adult muscle (2). We investigated whether the difference was related to alterations in protein synthesis vs. protein degradation.…”
Section: Regulation Of Protein Metabolism In Preclinical Models Of DImentioning
confidence: 96%
“…Nonetheless, it appears likely that MPB, if it is appreciably elevated in humans during disuse, happens early and then is likely adaptively reduced with longer periods of disuse. If MPB were not downregulated, as MPS is (see above), then rates of reduction in muscle/muscle fiber loss in disuse would be far greater than those observed in multiple ground-based models of disuse (2). However, these mathematical estimates are based on assumptions, some of which have not been tested, and thus integrated measurements of MPS and MPB would be a valuable advance in this area.…”
Section: Regulation Of Protein Metabolism In Human Disuse Atrophy: Nomentioning
confidence: 99%
“…Following denervation, HDAC4 indirectly regulates myogenin expression, thereby connecting neuronal activity to skeletal muscle transcriptional reprogramming of the neuromuscular junctions and compensatory reinnervation [35]. Considering its crucial role, HDAC4 has been proposed as a potential therapeutic target for diseases characterized by neurogenic muscle atrophy, such as ALS or SMA, or for sarcopenia [36][37][38][39]. Any pharmacological treatment with HDAC4 inhibitors for these conditions should be continued for months or years.…”
Section: Introductionmentioning
confidence: 99%