“…It is thus imperative to investigate mechanisms accounting for the age‐related muscle loss and functional decline. Changes at all levels, including gene expression, histone modification, DNA methylation, and physical changes in muscle stem cell environment, or niche, have been found to be associated with aging (Liu et al, ; Sahu et al, ; Stearns‐Reider et al, ; Su et al, ; Vinel et al, ; Zykovich et al, ). For instance, one of the studies of gene expression in aging muscle revealed that mitochondrial dysfunction is a major age‐related phenomenon and highlighted the beneficial effects of maintaining a high physical capacity in the prevention of age‐related muscle function decline (Su et al, ).…”