2017
DOI: 10.18632/aging.101303
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Abstract: Aging is accompanied by an increase in markers of innate immunity. How aging affects neutrophil functions remains of debate. The adenosine A2A receptor (A2AR), essential to the resolution of inflammation, modulates neutrophil functions. We sought to determine whether or not A2AR protects against the effects of aging. We monitored neutrophil influx, viability, and activation as well as cytokine accumulation in wild-type (WT) and A2AR-knockout mice (KO) at three different ages.Several readouts decreased with agi… Show more

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Cited by 5 publications
(2 citation statements)
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“…Our results also suggested that the probability of airway intervention decreases in older patients. This could be explained because age may reduce acute inflammatory response [ 20 ], which could decrease the risk of sudden upper airway obstruction in supraglottitis.…”
Section: Discussionmentioning
confidence: 99%
“…Our results also suggested that the probability of airway intervention decreases in older patients. This could be explained because age may reduce acute inflammatory response [ 20 ], which could decrease the risk of sudden upper airway obstruction in supraglottitis.…”
Section: Discussionmentioning
confidence: 99%
“…Further investigations are needed to better characterize the therapeutic potential of A 2A AR agonists in IBDs. A number of evidences reported that aging is often associated with a chronic, low-grade systemic inflammatory condition ( Laflamme et al, 2017 ), that could predispose to the gastrointestinal alterations typical of the elderly subject ( Remond et al, 2015 ). Recently, it has been demonstrated that the reduction of A 2A AR in the digestive tract of aged mice, contributes to an increased inflammation and lower ability to counteract gut infection with deleterious effects in the elderly ( Rodrigues et al, 2016 ).…”
Section: P1 Adenosine Receptorsmentioning
confidence: 99%