Age-related changes of serum bone alkaline phosphatase and cross-linked C-telopeptides of type I collagen and the relationship with bone mineral density in Chinese women

The conclusiveness of less‐invasive imaging techniques (computer tomography, X‐ray) with regard to their identification of bone diseases in a primate model (Callithrix jacchus)

“…However, a negative correlation between AP and breaking strength of the bones could be detected in this study. This is comparable to the human situation, where the AP increase is correlated with BMD decrease [31] and hence with reduced breaking strength of the bones [29]. The highest AP levels as well as the widened borders of osteoid in the common marmosets with low elastic modulus (animal 1–3) might be explained by the reaction of the enzyme AP, which is shaped by osteoblasts.…”

Evaluation of serum bone alkaline phosphatase activity in patients with liver disease: Comparison between electrophoresis and chemiluminescent enzyme immunoassay

“…Validation requirements have increased with further developments and progress in clinical laboratory technology. A major necessity is to uncover the limitations of currently used detection methods, to avoid such A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 17 errors in clinical applications and to maximally exploit the advantages of the methods used.…”

“…Humans in infancy and at puberty show 2 physiological blood bone ALP concentration peaks, with troughs in mid-childhood and at the end of adolescence [14,15]. Furthermore, for postmenopausal women with high bone turnover, bone ALP concentrations were found to be significantly higher than for those in premenopausal [16][17][18].…”

Relationship between Bone Turnover and Bone Density at the Proximal Femur in Stroke Patients

“…11 Previous studies showed the relationship between bone turnover and bone mineral density (BMD) in peri-and postmenopausal women. 12,13 Accelerated bone turnover as shown by biochemical markers has been suggested as an independent risk factor for fractures in postmenopausal osteoporosis. 14 Bone turnover markers are thought to be beneficial following the response to treatment as well.…”