Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

Ravikiran, Tekupalli; Ramachandregowda, Sowbhagya; Anupama, Sindhghatta Kariyappa; Anand, Santosh; Dundaiah, Bhagyalakshmi

doi:10.1007/s11010-016-2754-6

Cited by 7 publications

(16 citation statements)

References 45 publications

(48 reference statements)

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“…[4] Recent studies from our laboratory have demonstrated that dietary supplementation of Dh extract along with swim exercise helps in attenuating the OS in the aging rat brain. [5] Our studies also demonstrated that 4-HIA and EA are the major phenolic acids which exhibit potent antioxidant activities and inhibits lipid peroxidation (LPO) against AAPH induced OS in rat brain in vitro . [6] Therefore, the present study was hypothesized to investigate the effects of dietary supplementation of Dh extract, EA, and 4-HIA in curtailing the OS in the aging rat brain.…”

Section: Introductionmentioning

confidence: 77%

Modulatory effects of Decalepis hamiltonii extract and its compounds on the antioxidant status of the aging rat brain

et al. 2017

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Objective:The present study was aimed to investigate the neuroprotective effects of Decalepis hamiltonii (Dh) aqueous root extract and its compounds against age-related oxidative stress (OS) in the discrete regions of the rat brain.Materials and Methods:Male Wistar albino rats of 4- and 22-month-old were divided into control and six supplemented groups. The supplemented groups were orally administered with ellagic acid (EA), 4-hydroxyisophthalic acid (4-HIA), and Dh extract for 30 days.Results:Age-related decrease in antioxidant enzyme activities was noticed. The hippocampus was found to be more vulnerable to OS as seen by the elevation in the OS markers. Supplementation of the Dh extract, EA, and 4-HIA was found to be effective in up-regulating the antioxidant status. However, the extent of up-regulation was more evident in Dh supplemented animals.Conclusion:Our results suggest that Dh extract and its compounds exhibit neuroprotective effects against age-related OS and can be used as a dietary therapeutic intervention for the treatment of neurological disorders.

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Section: Introductionmentioning

confidence: 77%

Modulatory effects of Decalepis hamiltonii extract and its compounds on the antioxidant status of the aging rat brain

et al. 2017

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“…Oxidative stress in brain is related with many factors such as environmental toxin, aging, and diseases. Previous studies have shown oxidative stress could be alleviated by environmental enrichment ( 17 , 24 , 53 ), and the dramatic effect can be shown in the aging rat brain ( 17 , 24 ). EE also mediates various functional improvements via the increased expression of growth factors such as FGF-2 in the hypoxic ischemic mice ( 14 ).…”

Section: Discussionmentioning

confidence: 98%

“…Environmental enrichment (EE) is a rehabilitation strategy for rodents and the enhancement of the brain by surroundings that include various objects such as running wheels, novel toys and allow large social interactions to experience the effects of a complex combination of physical, cognitive, and social stimulation in the brain ( 14 – 16 ). In many studies, EE has been implicated in improvement of the brain functions such as neuroprotection and neurogenesis in an animal model of aging ( 17 – 20 ), ischemic brain injury ( 14 ), and neurodegenerative diseases ( 14 , 21 ). These diseases and brain injuries, accompanied with an increase in oxidative stress and olfactory impairment, eventually lead to a clinically significant problem ( 22 , 23 ).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Environmental Enrichment on Glutathione-Mediated Xenobiotic Metabolism and Antioxidation in Normal Adult Mice

et al. 2018

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Olfactory bulb (OB) plays an important role in protecting against harmful substances via the secretion of antioxidant and detoxifying enzymes. Environmental enrichment (EE) is a common rehabilitation method and known to have beneficial effects in the central nervous system. However, the effects of EE in the OB still remain unclear. At 6 weeks of age, CD-1® (ICR) mice were assigned to standard cages or EE cages. After 2 months, we performed proteomic analysis. Forty-four up-regulated proteins were identified in EE mice compared to the control mice. Gene Ontology analysis and Kyoto Encyclopedia of Genes and Genomes Pathway demonstrated that the upregulated proteins were mainly involved in metabolic pathways against xenobiotics. Among those upregulated proteins, 9 proteins, which participate in phase I or II of the xenobiotic metabolizing process and are known to be responsible for ROS detoxification, were validated by qRT-PCR. To explore the effect of ROS detoxification mediated by EE, glutathione activity was measured by an ELISA assay. The ratio of reduced glutathione to oxidized glutathione was significantly increased in EE mice. Based on a linear regression analysis, GSTM2 and UGT2A1 were found to be the most influential genes in ROS detoxification. For further analysis of neuroprotection, the level of iNOS and the ratio of Bax to Bcl-2 were significantly decreased in EE mice. While TUNEL+ cells were significantly decreased, Ki67+ cells were significantly increased in EE mice, implicating that EE creates an optimal state for xenobiotic metabolism and antioxidant activity. Taken together, our results suggested that EE protects olfactory layers via the upregulation of glutathione-related antioxidant and xenobiotic metabolizing enzymes, eventually lowering ROS-mediated inflammation and apoptosis and increasing neurogenesis. This study may provide an opportunity for a better understanding of the beneficial effects of EE in the OB.

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“…Functional improvements in neurological diseases have been proven by EE in several studies [ 17 ]. Moreover, various neurochemical and histological hypotheses have been suggested for the underlying mechanisms of this improvement, including reduced oxidative stress, anti-neuroinflammation, neurogenesis, synaptic plasticity, and neuroprotection via the induction of neurotrophic factors [ 18 , 19 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

et al. 2020

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Although environmental enrichment (EE) is known to reduce oxidative stress in Parkinson’s disease (PD), the metabolic alternations for detoxifying endogenous and xenobiotic compounds according to various brain regions are not fully elucidated yet. This study aimed to further understand the role of EE on detoxifying enzymes, especially those participating in phase I of metabolism, by investigating the levels of enzymes in various brain regions such as the olfactory bulb, brain stem, frontal cortex, and striatum. Eight-month-old transgenic PD mice with the overexpression of human A53T α-synuclein and wild-type mice were randomly allocated to either standard cage condition or EE for 2 months. At 10 months of age, the expression of detoxifying enzymes was evaluated and compared with wild-type of the same age raised in standard cages. EE improved neurobehavioral outcomes such as olfactory and motor function in PD mice. EE-treated mice showed that oxidative stress was attenuated in the olfactory bulb, brain stem, and frontal cortex. EE also reduced apoptosis and induced cell proliferation in the subventricular zone of PD mice. The overexpression of detoxifying enzymes was observed in the olfactory bulb and brain stem of PD mice, which was ameliorated by EE. These findings were not apparent in the other experimental regions. These results suggest the stage of PD pathogenesis may differ according to brain region, and that EE has a protective effect on the PD pathogenesis by decreasing oxidative stress.

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Age-related changes in the brain antioxidant status: modulation by dietary supplementation of Decalepis hamiltonii and physical exercise

Cited by 7 publications

References 45 publications

Modulatory effects of Decalepis hamiltonii extract and its compounds on the antioxidant status of the aging rat brain

Modulatory effects of Decalepis hamiltonii extract and its compounds on the antioxidant status of the aging rat brain

The Effect of Environmental Enrichment on Glutathione-Mediated Xenobiotic Metabolism and Antioxidation in Normal Adult Mice

Environmental Enrichment Attenuates Oxidative Stress and Alters Detoxifying Enzymes in an A53T α-Synuclein Transgenic Mouse Model of Parkinson’s Disease

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