2014
DOI: 10.3389/fnagi.2014.00209
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Abstract: To better understand the physiological mechanisms responsible for the differential motor cortex functioning in aging, we used transcranial magnetic stimulation to investigate interhemispheric interactions and cortical representation of hand muscles in the early phase of physiological aging, correlating these data with participants’ motor abilities. Right-handed healthy subjects were divided into a younger group (n = 15, mean age 25.4 ± 1.9 years old) and an older group (n = 16, mean age 61.1 ± 5.1 years old). … Show more

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Cited by 39 publications
(59 citation statements)
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“…There were reduced ICC values for the right hand compared with the left for iSP duration and latency. Coppi et al (2014) reported iSP duration to be longer for the left hand than the right, but this is the first study to demonstrate that the reliability may differ also. It is unclear why this was the case, but all participants in the current study were right handed and we therefore speculate that the non-dominant M1 may exert a more variable inhibitory influence on the dominant M1 than vice versa.…”
Section: Discussionmentioning
confidence: 60%
See 1 more Smart Citation
“…There were reduced ICC values for the right hand compared with the left for iSP duration and latency. Coppi et al (2014) reported iSP duration to be longer for the left hand than the right, but this is the first study to demonstrate that the reliability may differ also. It is unclear why this was the case, but all participants in the current study were right handed and we therefore speculate that the non-dominant M1 may exert a more variable inhibitory influence on the dominant M1 than vice versa.…”
Section: Discussionmentioning
confidence: 60%
“…Previous studies have indicated a change in TCI with aging, with reduced duration and area of the silent period for older adults (McGregor et al, 2011; Davidson and Tremblay, 2013; Coppi et al, 2014), which physical activity may ameliorate (McGregor et al, 2011). The present study showed no clear difference in reliability between younger and older groups suggesting that reproducibility of these measures is not dependent on age.…”
Section: Discussionmentioning
confidence: 99%
“…While contralateral somatomotor cortical activation subserves movement execution, ipsilateral activation is associated with movement suppression as a result of transcortical inhibition [Liang et al, 2014; McGregor et al, in press; Perez et al, 2014; Vidal et al, 2014; Yamanaka et al, 2013]; see also [Cincotta and Ziemann, 2008] for a review. This transcortical inhibition is seen to diminish during aging and certain neurological conditions [Bradnam et al, 2013; Coppi et al, 2014; Rossiter et al, 2014; Sharples et al, 2014; Takechi et al, 2014; Thomalla et al, 2014] known to compromise response inhibition [Hu et al, 2012; Jahanshahi, 2013]. Thus, decreased activation of bilateral somatomotor cortices is consistent with lack of inhibition and prolonged SSRT.…”
Section: Resultsmentioning
confidence: 99%
“…23 Several studies suggest that upper-limb brain activity is mainly lateralized over the contralateral sensorimotor regions during unilateral motor task in healthy individuals, with differences pointing to a less-lateralized activation related to aging or complexity of the motor task. [24][25][26] However, a transfer of findings from arm to leg seems unjustified. In particular, a bihemispheric control of foot movements in healthy individuals has been hypothesized.…”
Section: Neural Control Of Lower-limb Motor Function and Normal Walkingmentioning
confidence: 99%