Age-related changes in GM1, GD1a, GT1b components of gangliosides in Wistar albino rats

Abstract

In this study, age-related changes of GM1, GD1a, GT1b fractions of gangliosides were investigated in whole brain of male Wistar albino rats. Insignificant increases were detected in GM1 values from the third to the 24th month, whereas GD1a and GT1b concentrations of ganglioside in 24-month-old rats decreased significantly as compared to 6-month-old rats. Although there were no significant differences in the GD1a/GT1b ratio of any groups, GM1/GD1a and GM1/GT1b ratios were significantly increased as compared to 6-month-old rats. The increase in the ratios of gangliosides are not due to an increase of GM1 fractions; they result from a decrease of GD1a and GT1b fractions of gangliosides. In conclusion, the concentration of ganglioside decreased with ageing.

Diet‐Induced Changes in Membrane Gangliosides in Rat Intestinal Mucosa, Plasma and Brain

“…The present data suggests that dietary ganglioside may affect brain development because an increase of ganglioside content in the brain may afford protection against neuronal injury (15,17) and induce neurite growth (1) and is also observed in well‐fed animals compared with undernourished animals (33,34). The present study agrees with previous results describing the pattern of major brain gangliosides (26,35). The lack of significant change in individual ganglioside patterns observed in the brain may be attributed to a short experimental period (2 weeks), the lack of change in ganglioside patterns in the plasma or specific control of individual ganglioside composition in the brain.…”