Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Bonasera, Stephen J.; Arikkath, Jyothi; Boska, Michael D.; Chaudoin, Tammy R.; DeKorver, Nicholas W.; Goulding, Evan H.; Hoke, Traci; Mojtahedzedah, Vahid; Reyelts, Crystal D.; Sajja, Balasrinivasa R.; Schenk, A. Katrin; Tecott, Laurence H.; Volden, Tiffany A.

doi:10.18632/aging.101040

Cited by 12 publications

(15 citation statements)

References 47 publications

(43 reference statements)

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“…Further, prominent cerebellar ataxia has been observed in aged (21–24 months old) compared to young (2–3 months old) C 57 BL/6 mice obtained from the same colony as the mice in this study [10]. Interestingly, this appeared to be strain-specific with no ataxia present in BALB mice of identical ages.…”

Section: Resultsmentioning

confidence: 53%

“…In humans, overall cerebellar volume decreases with age as shown by voxel-based morphometry [8] and is associated with age-related gait impairments including slow gait speed [9]. Aging is accompanied by a marked change in cerebellar gene expression patterns in both rodent models and humans [10] [11]. No age-related decrease in cerebellar granule cell number or density has been noted in rodent models [12] [13]; small decreases have been described in humans [14].…”

Section: Introductionmentioning

confidence: 99%

“…No age-related decrease in cerebellar granule cell number or density has been noted in rodent models [12] [13]; small decreases have been described in humans [14]. Aging is also associated with a strain-specific increase in excitatory synaptic puncta in the internal granule cell layer; however, these synapses show deficits in excitatory amino acid neurotransmission [10]. Loss of visualized synaptic boutons on Purkinje cell dendritic networks also accompanies age-related Purkinje cell involution and loss [15].…”

Section: Introductionmentioning

confidence: 99%

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Increased whole cerebellar serotonin in aged C57BL/6 mice

DeKorver

Lichty²,

Hart³

et al. 2017

Matters

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Mobility and locomotor impairments have high prevalence, morbidity, and significant mortality in older adult populations. Cerebellar functional changes have been implicated in the pathogenesis of these age-related mobility and gait deficits unrelated to stroke, Parkinson’s disease, or degenerative joint disease. We thus examined total cerebellar glutamate, glutamine, GABA, glycine, dopamine, norepinephrine, tryptophan, serotonin, alanine, threonine, and asparagine content from male 2–3-month (young, n = 6) and 21–24-month-old (aged, n = 6) C57BL/6 mice. Neurotransmitter and amino acid concentrations were determined by high-performance liquid chromatography followed with mass spectroscopy. We found a significant increase in cerebellar serotonin in aged versus young mice, but otherwise no significant phenotypic differences in measured neurotransmitter concentrations. Applying current thought about cerebellar aging and cerebellar serotonergic systems, we consider how this age-related increase in cerebellar serotonin may contribute to gait ataxia.

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Section: Resultsmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased whole cerebellar serotonin in aged C57BL/6 mice

DeKorver

Lichty²,

Hart³

et al. 2017

Matters

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“…The cerebellar cortex is a frequently used model in neuroscience research in general and particularly for the study of age changes in the CNS neurons including deep cerebellar nuclei and neurons of the basal ganglia [134,135]. Recent studies suggest that the cerebellum is an excellent model for the study of the age-related changes at the cellular level [136,137]. Recent studies provide a clue to void the unwanted age-related disorders, first caloric restriction which retards the aging process as it selectively attenuates the age associated induction of genes encoding inflammatory and stress response.…”

Section: Resultsmentioning

confidence: 99%

“…The cerebellum is a vital organ that, besides playing a fundamental role in the postural control, equilibrium and motor coordination, is also involved in cognitive functions such as forgetfulness, decreased ability to maintain focus and decreased problem-solving capability. Owing to its architectural and cellular simplicity, the cerebellum provides an excellent model for the study of the age-related changes at the cellular level [4,5].…”

Section: Introductionmentioning

confidence: 99%

Structural, Metabolic Efficiency and Functional Monitoring of the Cerebellum and Basal Ganglia during Aging

Saber¹,

El-Aleem²,

Abdelwahab³

2018

CTB

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Additionally, the basal ganglia have received much attention during the last decades mainly because of their clinical relevance. It is now generally accepted that the basal ganglia are involved in a variety of non-motor functions, including those related to incentive and motivated behaviors. It is now clear that, in addition to afferents from the cerebral cortex, the Substantia Nigra Compacta (SNc) and thalamus, the basal ganglia receive many inputs from other sub-cortical structures, including the cerebellum, the locus coeruleus, the raphe

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Age-related changes in cerebellar and hypothalamic function accompany non-microglial immune gene expression, altered synapse organization, and excitatory amino acid neurotransmission deficits

Cited by 12 publications

References 47 publications

Increased whole cerebellar serotonin in aged C57BL/6 mice

Increased whole cerebellar serotonin in aged C57BL/6 mice

Structural, Metabolic Efficiency and Functional Monitoring of the Cerebellum and Basal Ganglia during Aging

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