Abstract:ABSTRACT. In an attempt to understand the dvnamic change of the gonadotropin-releasing horm~ne-~i"tuitar~ axis during the transitional stage from prepuberty to puberty, we investigated gonadotropin secretory patterns using a highly sensitive assay system and frequent blood sampling technique in children with Turner syndrome aged 5-17 y. Blood samples were collected every 20 min for 24 h in 16 cases, or every 30 min for 9 h (daytime 5 h, nighttime 4 h) in nine cases. Serum LH and FSH were measured by time-resol… Show more
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