Age-related cataract: GSTP1 ubiquitination and degradation by Parkin inhibits its anti-apoptosis in lens epithelial cells

Unbalanced redox status network as an early pathological event in congenital cataracts

“…GGCT has been linked to glutathione homeostasis in the context of cancer cells, but not in cataracts [ 49 ]. Reduced expression of GSTP1, an antioxidant protein, has been observed in age-related cataracts, possibly connected to promoter hypermethylation [ 50 ] or more recently to proteolytic degradation via the Parkin E3 ligase [ 51 ]. HMOX1 is a well-characterized downstream target of the NRF2 antioxidant transcription factor and has been extensively studied in lens epithelial cells, particularly because of its roles in regulation of ferroptosis [ 52 , 53 ].…”

“…Our analysis here indicates that redox regulation is impaired, however, the mechanisms for this are unclear. Several of the proteins we have identified as decreased in the K6W-Ub lenses are known to be regulated by the ubiquitin proteasome pathway, including HMOX1 and GSTP1 [ 51 , 79 ]. Additionally, the rate limiting enzyme for taurine synthesis, cysteine dioxygenase (CDO1) is also regulated by the ubiquitin proteasome system [ 80 ].…”

Comparison of postoperative visual performance between trifocal intraocular lens and monofocal intraocular lens

“…C ataract is the first reversible blindness-causing eye disease worldwide; however, the underlying pathogenesis is yet inconclusive. Albeit age and some genetic factors 1,2 are the main causes of cataract formation. With the overall improvement in the social, economic, and medical development, the patients have put forward high requirements for the postoperative effect of cataract.…”