2017
DOI: 10.1056/nejmoa1707572 View full text |Buy / Rent full text
Has erratum 2019-8-29
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Abstract: The age of transfused red cells did not affect 90-day mortality among critically ill adults. (Funded by the Australian National Health and Medical Research Council and others; TRANSFUSE Australian and New Zealand Clinical Trials Registry number, ACTRN12612000453886 ; ClinicalTrials.gov number, NCT01638416 .).

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“…19 While large RCTs have not associated PRBC age with mortality, these RCTs did not test PRBCs at the end of shelf life. 79,21 …”
Section: Discussionmentioning
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“…19 While large RCTs have not associated PRBC age with mortality, these RCTs did not test PRBCs at the end of shelf life. 79,21 …”
Section: Discussionmentioning
“…Although there are evidences reporting the potential harm of transfusing stored RBCs [1,2,3,4,5,6,7,8,9,10,11], other studies on randomized clinical trials reported no difference in mortality of patients who received fresher versus older RBCs [23,24,25,26]. Most published clinical studies are non-randomized observational studies with methodologic limitations.…”
Section: Discussionmentioning
“…RECESS4 enrolled adults having scheduled complex cardiac surgery. TRANSFUSE6 and ABLE3 enrolled adults admitted to critical care units. INFORM5 enrolled a broad patient population, but many participants were at low risk of death (the trial’s primary outcome), which may be a limitation when evaluating the clinical consequences of storage duration.…”
Section: Importance Of Case MIXmentioning
“…Establishing clinical consequences of storage effects on red blood cells would be of major importance for blood transfusion services. The four most recent randomised trials (ABLE,3 RECESS,4 INFORM,5 and TRANSFUSE6; box 1) analysed nearly 30 000 patients who received transfusions, reporting neither benefit nor harm from cells with different storage durations. These results should provide adequate reassurance that storage duration has no clinical impact.…”
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